1,2,3-Trichloropropane

Agent Name
1,2,3-Trichloropropane
CAS Number
96-18-4
Formula
C3-H5-Cl3
Major Category
Solvents
1,2,3-Trichloropropane formula graphical representation
Synonyms
1,2,3-Trichloropropane; Allyl trichloride; Glycerol trichlorohydrin; Glyceryl trichlorohydrin; Trichlorohydrin; Trichloropropane; [ChemIDplus] UN2810
Category
Chlorinated Aliphatics
Description
Colorless liquid with a chloroform-like odor; [NIOSH]
Sources/Uses
Used as a curing agent for polysulfides and a chemical intermediate; Used in the past as a solvent and extractive agent; [ACGIH] Used as a degreaser, paint remover, and solvent for resins, waxes, and oils; [HSDB]
Comments
Mice have hepatic damage and die after exposure to 5000 ppm for 20 minutes. Rats and guinea pigs have CNS depression after exposures to 800, 2100, or 5000 ppm for 30 minutes. Workers complained of unpleasant odor and irritation of the eyes and throat at 100 ppm. TLV Basis is cancer. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury; Inhalation of high concentrations can cause CNS depression; [ICSC]
Biomedical References

Exposure Assessment

TLV (ACGIH)
0.005 ppm
PEL (OSHA)
50 ppm
IDLH (NIOSH)
100 ppm
Excerpts from Documentation for IDLHs
It has been reported that objectionable ocular and mucosal irritation were experienced after 15 minutes of exposure to 100 ppm [Silverman et al. 1946].
Vapor Pressure
3.69 mm Hg
Odor Threshold Low
100 ppm
Lethal Concentration
LCLo (rat) = 500 ppm/4H
Explanatory Notes
Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 180 deg F; VP from HSDB;
Half Life
Animal studies (whole body): 1 day; [TDR, p. 1194]
NFPA
high ambient temp required

Adverse Effects

Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Nephrotoxin
Yes
IARC Carcinogen
Probable (2a)
NTP Carcinogen
Anticipated human carcinogen
ACGIH Carcinogen
Suspected Human

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: