Cycloposine
Agent Name
Cycloposine
CAS Number
23185-94-6
Formula
C33-H51-N-O7
Major Category
Biological Agents
Synonyms
3-Glucosyl-11-deoxojervine; beta-D-Glucopyranoside, (3beta,23beta)-17,23-epoxyveratraman-3-yl; 17,23beta-Epoxyveratraman-3beta-yl-beta-D-glucopyranoside; [ChemIDplus]
Category
Plant Toxins
Sources/Uses
A steroid alkaloid of the Veratrum genus; No longer used as an antihypertensive drug; [HSDB]
Comments
Increases the permeability of sodium channels in nerve cells causing continuous stimulation; After ingestion, causes vomiting and abdominal pain followed by hypotension and arrhythmias; Teratogenic in animals; Emergency treatment: "Plants- veratrum alkaloids"; Excessive amounts of veratrum alkaloids can cause death by central respiratory depression; [HSDB] Veratrum alkaloids (e.g., black snakeroot, false hellebore, and skunk cabbage) cause gastroenteritis, bradycardia, paresthesias, AV block, and syncope;; [Olson, p. 376-92]
Biomedical References
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.