Diphenylamine

Agent Name
Diphenylamine
CAS Number
122-39-4
Formula
C12-H11-N
Major Category
Nitrogen Compounds
Diphenylamine formula graphical representation
Synonyms
Aniline, N-phenyl-; Anilinobenzene; Benzenamine, N-phenyl-; Benzene, (phenylamino)-; Benzene, anilino-; Big Dipper; C.I. 10355; CI 10355; DFA; DPA (VAN); Deccoscald 282; Difenylamin [Czech]; Diphenylamine; N,N-Diphenylamine; N-Fenylanilin [Czech]; N-Phenylaniline; N-Phenylbenzenamine; Naugalube 428L; No-Scald; No-Scald DPA 283; Phenylaniline; Scaldip; Shield DPA; [ChemIDplus] UN3077
Category
Amines, Polyaromatic
Description
Colorless, tan, amber, or brown crystalline solid with a pleasant, floral odor. (fungicide); [NIOSH]
Sources/Uses
Used as an antioxidant, stabilizer of explosives, fungicide, and analytical chemical reagent; also used in the manufacture of dyes and pesticides; [ACGIH] Used to make dyes, to stabilize nitrocellulose explosives and celluloid, to treat screwworm topically (veterinary), and to test for nitrate or nitrite poisoning; [Merck Index]
Comments
The toxicity of diphenylamine is similar to that of aniline. Hepatotoxic effects have been demonstrated in animals. It can cause bladder irritation and induce methemoglobinemia in workers. As a skin sensitizer it cross-reacts with p-phenylene diamine. [ACGIH] May have effects on the kidneys and blood; A skin, eye, and respiratory tract irritant; [ICSC]
Reference Link #1
Biomedical References

Exposure Assessment

BEI
Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
10 mg/m3
MAK
5 mg/m3, inhalable fraction
Vapor Pressure
0.00067 mm Hg
Odor Threshold Low
0.02 ppm
Explanatory Notes
Odor threshold from AIHA; Flash point = 307 deg F; VP from HSDB;
Reference Link #2
NFPA
must be preheated

Adverse Effects

Skin Sensitizer
Yes
Methemoglobinemia
MetHgb is primary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Nephrotoxin
Yes
IARC Carcinogen
Possible (2b)
ACGIH Carcinogen
Not Classifiable

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: