Disulfiram

Synonyms

1,1'-Dithiobis(N,N-diethylthioformamide); Abstensil; Abstensyl (Argentina); Abstinil; Abstinyl; Accel TET; Accel TET-R; Alcophobin; Alk-aubs; Antabus; Antabuse; Antadix; Antaenyl; Antaethyl; Antaetil; Antalcol; Antetan; Antetil; Anteyl; Anti-ethyl; Antiaethan; Anticol; Antietanol; Antietil; Antikol; Antivitium; Antivitium (Spain); Aversan; Averzan; Bis((diethylamino)thioxomethyl) disulfide; Bis((diethylamino)thioxomethyl)disulphide; Bis(N,N-diethylthiocarbamoyl) disulfide; Bis(N,N-diethylthiocarbamoyl)disulphide; Bis(diethylthiocarbamoyl) disulfide; Bis(diethylthiocarbamoyl)disulphide; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfiram; Disulfirame [DCIT]; Disulfiramo [INN-Spanish]; Disulfiramum [INN-Latin]; Dupon 4472; Dupont fungicide 4472; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ephorran; Esperal [France]; Etabus; Ethyl TUEX; Ethyl thiram; Ethyl thiurad; Ethyl tuads; Ethyldithiourame; Ethyldithiurame; Exhorran; Formamide, 1,1'-dithiobis(N,N-diethylthio-; HOCA; HocakrotenalKrotenal; N,N,N',N'-Tetraethylthiuram disulfide; N,N,N',N'-Tetraethylthiuram disulphide; Nocbin; Nocceler TET; Nocceler TET-G; Noxal; Noxal (VAN); Refusal; Refusal [Netherlands]; Ro-Sulfiram; Ro-Sulfram-500 (USA); Sanceler TET; Sanceler TET-G; Soxinol TET; Stopetyl; TATD; TETD; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradine; Tetraethylthioperoxydicarbonic diamide; Tetraethylthiram disulfide; Tetraethylthiram disulphide; Tetraethylthiuram disulfide; Tetraethylthiuram disulphide; Tetraethylthiuran disulfide; Tetraethylthiurium disulfide; Tetraetil; Teturam; Teturamin; Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-; Thiosan; Thioscabin; Thiuram E; Thiuram disulfide, tetraethyl-; Thiuranide; Tiuram; Tuads, ethyl; [ChemIDplus]

Category

Dithiocarbamates (Pesticide)

Description

White, yellowish, or light-gray powder with a slight odor.(fungicide); [NIOSH]

Sources/Uses

Used as a fungicide, a rubber accelerator, and a drug to treat alcoholism; [ACGIH]

Comments

Disulfiram is tested in the standard allergen tray as one of the components of the thiuram mix (tetraethylthiuram disulfide); Thiuram-sensitive patients who take Antabuse may develop a generalized contact dermatitis or localized hand and foot dermatitis. [Marks, p. 132] A nurse dispensing disulfiram developed contact dermatitis; [Kanerva, p. 1837] Drug-induced hepatitis has been rarely reported in patients taking therapeutic doses of Antabuse. [HSDB] Poisoning by ingestion (with alcohol): headache, flushing, hypotension, sweating, dizziness, nausea, vomiting, and diarrhea; Poisoning by ingestion (acute overdose): delirium, agitation, CNS depression; Poisoning by ingestion (chronic overdose): encephalopathy and neuropathy; [Ford, p. 591-4]

Reference Link #1

Biomedical References

Insufficient data

2 mg/m3

2 mg/m3, inhalable fraction

0.00087 mm Hg

Explanatory Notes

VP from HSDB;

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Not classifiable

Not Classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic