1,2-Benzenediamine dihydrochloride

Agent Name
1,2-Benzenediamine dihydrochloride
CAS Number
615-28-1
Formula
C6-H8-N2.2Cl-H
Major Category
Nitrogen Compounds
1,2-Benzenediamine dihydrochloride formula graphical representation
Synonyms
o-Phenylenediamine dihydrochloride; 1,2-Phenylenediamine dihydrochloride; [ChemIDplus] UN1673
Category
Amines, Aromatic
Description
Brownish-yellow solid; [CAMEO]
Sources/Uses
Used to make dyes; [CAMEO] Not commercially produced in the US; [HSDB]
Comments
Has the potential to form methemoglobin; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS]; Harmful by ingestion, inhalation, or skin absorption; May cause allergic skin reaction; Suspected cause of cancer and genetic defects; [Aldrich MSDS] See "p-Phenylenediamine."
Biomedical References

Exposure Assessment

Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Phenylenediamines."

Adverse Effects

Skin Sensitizer
Yes
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: