2,4-Diaminophenol dihydrochloride

Synonyms

2,4-Diaminophenol HCl; 2,4-Diaminophenol hydrochloride; Acrol; Amidol; Diamidophenol hydrochloride; Dianol; Phenol, 2,4-diamino-, dihydrochloride; [ChemIDplus]

Category

Amino Phenols

Description

Grayish-white solid; [HSDB] Slightly gray crystalline solid; [MSDSonline]

Sources/Uses

Used as photographic developer, analytical reagent, and in fur and hair dyeing; [HSDB]

Comments

Limited evidence of mutagenicity and carcinogenicity in male mice; No evidence of carcinogenicity in female mice or male and female rats; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] May cause irritation and allergic reactions; [CAMEO] Causes changes in liver and bladder weight, erythrocyte count, and levels of transaminases in high-dose feeding studies of mice; [RTECS] See "p-Phenylenediamine."

Biomedical References

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Dressing Hair
• Fur Dressing and Dyeing
• Photographic Processing