Ethyl methylphenylglycidate
Agent Name
Ethyl methylphenylglycidate
CAS Number
77-83-8
Formula
C12-H14-O3
Major Category
Other Classes
Synonyms
3-Methyl-3-phenyloxiranecarboxylic acid, ethyl ester; 2,3-Epoxy-3-phenylbutyric acid, ethyl ester; 3-Methyl-3-phenylglycidic acid ethyl ester; Aldehyde C-16; Butanoic acid, 2,3-epoxy-3-phenyl-, ethyl ester; C-16 aldehyde; EMPG; Ethyl 2,3-epoxy-3-methyl-3-phenylpropionate; Ethyl 3-methyl-3-phenylglycidate; Ethyl 3-methyl-3-phenyloxiranecarboxylate; Ethyl alpha,beta-epoxy-beta-methylhydrocinnamate; Ethyl alpha,beta-epoxy-beta-methylphenylpropionate; Ethyl ester of 2,3-epoxy-3-phenylbutanoic acid; Ethyl(methylphenyl)glycidate; Fraeseol; Hydrocinnamic acid, alpha,beta-epoxy-beta-methyl-, ethyl ester; Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl ester; Strawberry aldehyde; alpha,beta-Epoxy-beta-methylhydrocinnamic acid, ethyl ester; [ChemIDplus]
Category
Esters, Other
Description
Colorless to light-yellow liquid with a strong odor like fruit or berries; [HSDB] Colorless liquid; [MSDSonline]
Sources/Uses
Used in perfumes and flavors; [Hawley]
Comments
A mutagen; Causes somnolence and change in liver enzymes in high-dose rat feeding studies; [RTECS] Acceptable daily intake = 0-0.5 mg/kg bw; [JECFA] Caused no skin irritation or sensitization in 25 human volunteers (1% in petrolatum); Effects in 16 week feeding study with rats at 10000 ppm include testicular atrophy; Observations in two year feeding study with rats include hindquarter paralysis and histopathological changes to sciatic nerve; No histopathological organ changes or evidence of carcinogenicity in long term feeding studies; [HSDB]
Biomedical References
Exposure Assessment
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.