Fusarenon X

Synonyms

12,13-Epoxy-3-alpha,4-beta,7-alpha,15-tetrahydroxytrichothec-9-en-8-one 4-acetate; 3,7,15-Trihydroxy-4-acetoxy-8-oxo-12,13-epoxy-delta(sup 9)-trichothecene; 3alpha,7alpha,15-Trihydroxy-4beta-acetoxy-12,13-epoxytrichothec-9-en-8-one; 4-Acetyloxy-12,13-epoxy-3,7,15-trihydroxy-(3-alpha,4-beta,7-alpha)-trichothec-9-en-8-one; Fusarenon; Fusarenone X; Nivalenol monoacetate; Nivalenol-4-O-acetate; Trichothec-9-en-8-one, 12,13-epoxy-3alpha,4beta,7alpha,15-tetrahydroxy-, 4-acetate; Trichothec-9-en-8-one, 4-(acetyloxy)-12,13-epoxy-3,7,15-trihydroxy-, (3alpha,4beta,7alpha)-; [ChemIDplus]

Category

Mycotoxins

Description

Transparent solid; [HSDB]

Sources/Uses

A mycotoxin produced by Fusarium nivale; [ChemIDplus] Zearalenone, deoxynivalenol, and fusarenon X are mycotoxins produced by three Fusarium species (F. graminearum, F. culmorum, and F. crookwellense) that grow on wheat, barley, and maize in humid conditions. [IARC] Human exposure to Fusarenon X is rare; [IARC]

Comments

Trichothecene mycotoxins causes bone marrow suppression, leukopenia, immunosuppression, and secondary sepsis; [HSDB] Causes diarrhea and muscle weakness at lethal doses fed to rats; Causes hepatocellular necrosis in cats after subcutaneous doses; [RTECS] LD50 (mice) = 3-5 mg/kg by all routes; Causes cellular destruction in rapidly dividing cells of the GI tract, thymus, lymph nodes, spleen, bone marrow, ovaries, and testes; Exposed animals have diarrhea, food refusal, and vomiting; Highly irritating to the skin of animals causing necrosis of hair follicles and dermis; [IARC] See "T-2 toxin."

Reference Link #1

Biomedical References

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Not classifiable

Other Information

No other related information on this agent was found.