Hexachlorodibenzo-p-dioxin

Synonyms

HCDD; Hexachlorodibenzo-4-dioxin; Dibenzo(b,e)(1,4)dioxin, hexachloro-; Dibenzo-p-dioxin, hexachloro-; Hexachlorodibenzodioxin; [ChemIDplus]

Category

Halogenated Polyaromatics

Sources/Uses

Found as impurity in pesticides and pentachlorophenol (wood preservative); Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB]

Comments

IARC classification is for polychlorinated dibenzo-para-dioxins other than 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); Polychlorodibenzodioxins have caused chloracne in humans; Occupational exposure may occur from contact with contaminated compounds (i.e. pesticides and pentachlorophenol), in metal reclamation, or during manufacture of chlorophenols; 1,2,3,4,7,8- isomer oral LD50 (rat) = 0.887 mg/kg; Effects in high-dose feeding studies with rats include hemorrhage, anemia, wasting syndrome, and changes in liver enzyme activity; Some evidence of increase in tumor frequency and teratogenicity; [HSDB] Significant exposure more likely through breast milk than transplacentally; Similar toxicity to TCDD, but less potent; [REPROTOX]

Biomedical References

4.4E-11 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Chloracne

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Chloracne