Monomethyl aniline

Synonyms

(Methylamino)benzene; Aniline, N-methyl-; Benzeneamine, N-methyl-; Methylphenylamine; Monomethylaniline; N-Methylaminobenzene; N-Methylbenzenamine; N-Methylphenylamine; N-Monomethylaniline; N-Phenylmethylamine; [ChemIDplus] UN2294

Category

Amines, Aromatic

Description

Yellow to light-brown liquid with a weak, ammonia-like odor; [NIOSH]

Sources/Uses

Used as a solvent and in organic synthesis; [ACGIH] Solvent for organic reactions and for nitrocellulose; [HSDB]

Comments

Methemoglobinemia and liver injury occur in animals exposed to high concentrations over a period of weeks and months. There are no reports of human poisoning by monomethyl aniline. Listed in table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] Can induce methemoglobinemia; [ICSC]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Yes

0.5 ppm

2 ppm

0.5 ppm

100 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that a dog survived 50 seven­hour exposures to 86 ppm [Treon et al. 1949].

0.453 mm Hg

1.6 ppm

Odor Threshold High

2 ppm

Explanatory Notes

Odor threshold from AIHA; Flash point = 175 deg F; VP from HSDB;

MetHgb is primary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Methemoglobinemia, acute