Menthone
Agent Name
Menthone
CAS Number
89-80-5
Formula
C10-H18-O
Major Category
Biological Agents
Synonyms
5-Methyl-2-(1-methylethyl)cyclohexanone, trans-; Cyclohexanone, 5-methyl-2-(1-methylethyl)-, trans-; Menthone (natural); Neomenthone; p-Menthan-3-one, trans-; p-Menthone; trans-Menthan-3-one; [ChemIDplus]
Category
Plant Oils and Extracts
Description
Colorless liquid with a mild odor of peppermint; [Hawley]
Sources/Uses
Ketone present in peppermint oil; [Hawley] Used in perfumes and flavorings; [HSDB] Peppermint oil contains menthol, menthone, and more than 30 other chemicals. It is widely used as a flavoring agent and herbal remedy. [Haddad, p. 1439]
Comments
Emergency treatment: "Peppermint oil"; A mild skin irritant in rabbits; After oral dosing at 400-800 mg/kg/day for 28 days, rats have liver and kidney dysfunction and histopathological cysts in the white matter of the cerebellum; [HSDB] Peppermint oil causes CNS depression and hypothermia in rat feeding studies; [Haddad, p. 1439] Safe when used as a flavoring agent in food; [JECFA]
Biomedical References
Exposure Assessment
Vapor Pressure
0.278 mm Hg
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.