Piperazine dihydrochloride

Synonyms

Diethylenediamine dihydrochloride; Dihydro Pip Wormer; Dihydrochloride salt of diethylenediamine; Dowzene DHC; Piperazine dihydrochloride; Piperazine wormer premix; [ChemIDplus]

Category

Piperazines

Description

White to cream-colored needles or powder; [NIOSH]

Sources/Uses

Used to manufacture fibers, pharmaceuticals, and insecticides; [ACGIH] Used as a veterinary anthelmintic medication and a curing agent for polychloroprene; [HSDB]

Comments

Piperazine dihydrochloride is well tolerated as an oral medication at a dose of 150 mg/kg for several days. Skin burns, allergic contact dermatitis, and asthma have been reported after occupational exposures to piperazine dust. [ACGIH] Piperazine, CAS # 110-85-0, is corrosive to skin. [Quick CPC] Asthma reported in pharmaceutical and chemical production workers; [Malo] Allergic contact dermatitis reported in pharmaceutical, laboratory, healthcare, and veterinary workers; [Kanerva, p. 1827] See "Piperazine and salts."

Reference Link #1

Biomedical References

Explanatory Notes

TLV withdrawn 2012;

Yes

Yes

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Plastic Composites Manufacturing