N-Methylacetamide
Agent Name
N-Methylacetamide
CAS Number
79-16-3
Formula
C3-H7-N-O
Major Category
Nitrogen Compounds
Synonyms
Methyl acetamide; Acetamide, N-methyl-; Acetamide, methyl-; Acetic acid, amide, N-methyl; Methylacetamide; Monomethylacetamide; N-Methyl acetamide; N-Monomethylacetamide; X 44; [ChemIDplus]
Category
Other Nitrogen Compounds
Description
Solid; mp = 28 deg C; [HSDB] White crystalline solid; mp = 26-28 deg C; [Alfa Aesar MSDS]
Sources/Uses
Used as a solvent, in electrochemistry, and as a pesticide registered with the EPA; [HSDB]
Comments
Mice that died 24-48 hours following administration exhibited toxic hepatitis, necrosis of pancreas, and testicular atrophy; Causes hyperglycemia in rats; A diabetogen in experimental animals that produces an insulin-resistant state (rather than insulin deficiency); Teratogenic effects and embryotoxicity observed in rats and rabbits (dermal, gavage, and intraperitoneal routes); [HSDB] Causes changes in renal tubules, changes in bone marrow, and weight loss in 90-day constant feeding study of rats (90 gm/kg); [RTECS] An irritant; [Alfa Aesar MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
0.44 mm Hg
Explanatory Notes
VP from ChemIDplus;
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: