o-Toluenesulfonamide
Agent Name
o-Toluenesulfonamide
CAS Number
88-19-7
Formula
C7-H9-N-O2-S
Major Category
Nitrogen Compounds
Synonyms
2-Toluenesulfonamide; 2-Methylbenzenesulfonamide; 2-Tolylsulfonamide; Benzenesulfonamide, 2-methyl-; Toluene-2-sulfonamide; o-Methylbenzenesulfonamide; ortho-Toluenesulfonamide; ortho-Toluol-sulfonamid [German]; [ChemIDplus]
Category
Sulfonamides
Description
Colorless solid; [Hawley] White powder; [MSDSonline]
Sources/Uses
Used in mixtures with p-toluenesulfonamide as reactive plasticizer; Also used as a plasticizer for hot-melt adhesives and a chemical intermediate for fluorescent pigments and plasticizer resins; [HSDB] Used to make saccharin; [eChemPortal: SIDSUNEP] A contaminant of saccharin; [IARC]
Comments
A mutagen, tumorigen, reproductive effector, and moderate eye irritant; [RTECS] Used therapeutically, sulfonamides can cause a range of hypersensitivity reactions including rashes and injury to the liver and kidneys; Methemoglobinemia has been reported after overdose; [HSDB] An eye irritant; [ICSC] An irritant; [MSDSonline] See "p-Toluenesulfonamide" and "Toluenesulfonamide."
Biomedical References
Exposure Assessment
Vapor Pressure
6E-05 mm Hg
Adverse Effects
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.