Octabenzone

Synonyms

(2-Hydroxy-4-(octyloxy)phenyl)phenylmethanone; 2-Benzoyl-5-octyloxyphenol; 2-Hydorxy-4-octoxybenzophenone; 2-Hydroxy-4-(n-octoxy)benzophenone; 2-Hydroxy-4-(n-octyloxy)benzophenone; 2-Hydroxy-4-(octyloxy)benzophenon; 2-Hydroxy-4-(octyloxy)benzophenone; 2-Hydroxy-4-octoxybenzophenone; 2-Hydroxy-4-octyloxybenzophenone; 2-Hydroxy-4-oktyloxybenzofenon [Czech]; 4-(Octyloxy)-2-hydroxybenzophenone; 4-Octoxy-2-hydroxybenzophenone; 4-n-Octyloxy-2-hydroxybenzophenone; Aduvex 248; Advastab 46; Anti-UV P; Benzon OO; Benzophenone 12; Benzophenone, 2-hydroxy-4-(octyloxy)-; Biosorb 130; Carstab 700; Chimassorb 81; Cyasorb UV 531; Mark 1413; Methanone, (2-hydroxy-4-(octyloxy)phenyl)phenyl-; Octabenzona [INN-Spanish]; Octabenzonum [INN-Latin]; Rhodialux P; Sanduvor 3035; Seikalizer E; Spectra-Sorb UV 531; Sumisorb 130; UF 4; UNII-73P3618V2E; UV 1; UV 1 (ultroviolet absorber); UV 531; UVA 1; Uvinul 408; Uvinul M 408; Viosorb 130; Zislizer E; 2-Hydroxy-4-n-octyloxybenzophenone; [ChemIDplus]

Category

Sunscreens

Description

Colorless solid; [Hawley] Light yellow solid; [MSDSonline]

Sources/Uses

Used as an ultraviolet stabilizer for polyethylene and an ultraviolet sunscreen; [Merck Index]

Comments

Not irritating to skin or eyes of rabbits; Caused skin sensitization in a guinea pig study; [IUCLID] Oral LD50 (rat) >10,000 mg/kg; [ChemIDplus] Caused skin sensitization in guinea pig maximization test (60-78% positive), but not in human patch test study involving 50 people; Effects in high-dose animal studies (rats) include kidney injury; [MSDSonline] See "Oxybenzone."

Biomedical References

Yes

PACD (photoallergic contact dermatitis)

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Contact dermatitis, photoallergic