Streptozocin

Synonyms

2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-alpha(and beta)-D-glucopyranose; D-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-; D-Glucose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-; Estreptozocina [INN-Spanish]; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff [German]; N-D-Glucosyl-(2)-N'-nitrosomethylurea; NRRL 2697; STRZ; STZ; Streptozocine [INN-French]; Streptozocinium [Latin]; Streptozocinum [INN-Latin]; Streptozotocin; U 9889; U-9889; Zanosar; Glucopyranose, 2-deoxy-2-(3-methyl-3-nitrosoureido)-; [ChemIDplus]

Category

Bacterial Toxins

Description

Ivory-colored or pale yellow solid; [HSDB] Light yellow crystalline solid; [MSDSonline]

Sources/Uses

Produced by Streptomyces achromogenas (soil microorganisms); Used to produce diabetes in experimental animals and as an antineoplastic agent; [HSDB]

Comments

Emergency treatment: Symptomatic drug parenteral exposure; [HSDB] Causes diabetes mellitus and increase in liver enzymes in feeding studies of rats with a TDLo =55 mg/kg; [RTECS] Induces diabetes in animals, and diabetes affects pregnancy outcomes; [REPROTOX] May cause irritation; May be harmful by ingestion, inhalation, or skin absorption; Targets pancreas, liver, kidneys, blood, and reproductive system; [Aldrich MSDS]

Biomedical References

1.74E-12 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Possible (2b)

Anticipated human carcinogen

Other Information

No other related information on this agent was found.