Sulfolane
Agent Name
Sulfolane
CAS Number
126-33-0
Formula
C4-H8-O2-S
Major Category
Other Classes
Synonyms
1,1-Dioxidetetrahydrothiofuran; 1,1-Dioxidetetrahydrothiophene; 1,1-Dioxothiolan; 2,3,4,5-Tetrahydrothiophene-1,1-dioxide; Bondelane A; Bondolane A; Cyclic tetramethylene sulfone; Cyclotetramethylene sulfone; Dihydrobutadiene sulfone; Dihydrobutadiene sulphone; Dioxothiolan; Sulfalone; Sulfolan; Sulpholane; Sulphoxaline; Tetrahydrothiofen-1,1-dioxid [Czech]; Tetrahydrothiophene 1,1-dioxide; Tetrahydrothiophene dioxide; Tetramethylene sulfone; Thiacyclopentane dioxide; Thiocyclopentane-1,1-dioxide; Thiolane-1,1-dioxide; Thiophan sulfone; Thiophane dioxide; Thiophene, tetrahydro-, 1,1-dioxide; [ChemIDplus]
Category
Sulfur Compounds
Description
Liquid; mp = 27.4-27.8 deg C; [Merck Index] White solid; [HSDB] Colorless liquid; mp = 26 deg C; [CAMEO] Colorless solid; mp = 27 deg C; [SIDS UNEP] Colorless crystalline solid; mp = 25-28 deg C; [Alfa Aesar MSDS]
Sources/Uses
Used as a solvent (aromatics extraction and polymerization), plasticizer, curing agent (epoxy resins) and therapeutic (antibacterial, convulsant, and radiation-protective agent); Also used for acid gas purification, fractionation (wood tars, tall oil, and other fatty acids), and textile finishing; [HSDB] Used in electronic applications, pharmaceutical manufacturing (solvent), jet printing inks (solvent), and medicines (believed to exist only in patent literature); [SIDS UNEP]
Comments
Not irritating or sensitizing to rabbit skin; Mildly irritating to rabbit eyes; All rats convulsed during aerosolized exposure in lethal-concentration study; Convulsions observed in sub-chronic inhalation studies of dogs and monkeys and clonic-tonic convulsions noted in rats exposed by oral and parenteral routes; Intraperitoneal injection causes decreased metabolic rate and hypothermia in mice and rats; No evidence of mutagenicity; [HSDB] A mild eye irritant; [Alfa Aesar MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
0.0062 mm Hg
Lethal Concentration
LC50 (rat) > 12,000 mg/m3/4h
Explanatory Notes
LC (rat) > 250 mg/m3/8hr; [ChemIDplus] VP from ChemIDplus;
NFPA
must be preheated
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: