Tetramethylurea
Agent Name
Tetramethylurea
CAS Number
632-22-4
Formula
C5-H12-N2-O
Major Category
Nitrogen Compounds
Synonyms
1,1,3,3-Tetramethylurea; N,N,N',N'-Tetramethylurea; TMU; Temur; Tetramethyluree [French]; Urea, 1,1,3,3-tetramethyl-; Urea, tetramethyl-; Urea, N,N,N',N'-tetramethyl-; [ChemIDplus]
Category
Urea Compounds
Description
Liquid with mild pleasant odor; [Merck Index] Colorless liquid; [Alfa Aesar MSDS]
Sources/Uses
Used as solvent and reagent; [Merck Index]
Comments
Teratogenic effects observed in mice dosed by SC injection; IV doses of 150 mg/kg daily for five days produced weight loss in dogs, monkeys, and mice; [HSDB] A strong skin irritant, but not a sensitizer in guinea pigs; Temporary kidney injury and possible liver injury observed in two week feeding study of male rats at 450 mg/kg; [EPA] Causes general anesthesia and somnolence in IP lethal-dose study of mice; [RTECS] Teratogenic effects and fetal loss observed in studies of rodents; No human data on reproductive or lactation effects; [REPROTOX] An irritant; [Alfa Aesar MSDS]
Biomedical References
Exposure Assessment
Lethal Concentration
LCLo (rat) = 312 ppm/4h
Explanatory Notes
VP = 13.9 mm Hg at 71 deg C; [ChemIDplus]
Adverse Effects
Neurotoxin
Other CNS neurotoxin
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.