m-(Trifluoromethyl)aniline
Agent Name
m-(Trifluoromethyl)aniline
CAS Number
98-16-8
Formula
C7-H6-F3-N
Major Category
Nitrogen Compounds
Synonyms
1-Amino-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)aniline; 3-(Trifluoromethyl)benzenamine; 3-Aminobenzotrifluoride; 3-Trifluoromethyl aniline; Benzenamine, 3-(trifluoromethyl)-; Toluene, 3-amino-alpha,alpha,alpha-trifluoro-; alpha,alpha,alpha-Trifluoro-m-toluidine; m-ABTF; m-Amino-alpha,alpha,alpha-trifluorotoluene; m-Aminobenzal fluoride; m-Aminobenzotrifluoride; m-Toluidine, alpha,alpha,alpha-trifluoro-; 3-Trifluoromethylaniline; [ChemIDplus] UN2948
Category
Amines, Aromatic
Description
mp = 5.5 deg C; [ChemIDplus] Colorless to yellow liquid with a fishy odor; [HSDB] Colorless liquid; [MSDSonline]
Sources/Uses
Used as intermediate for phenothiazine derivatives, herbicides, antihypertensives, and diuretics; [HSDB] Used to make dyes; [CAMEO]
Comments
A moderate eye irritant; In lethal-dose feeding studies, causes methemoglobinemia, somnolence, and fatty liver degeneration; [RTECS] A corrosive chemical that could cause chemical pneumonitis after inhalation; Methemoglobinemia reported in animal experiments; Monitor liver and kidney function after significant exposure; [HSDB] May burn skin and eyes; [CAMEO] An irritant; Can be absorbed through skin; [MSDSonline]
Biomedical References
Exposure Assessment
Vapor Pressure
0.592 mm Hg
Lethal Concentration
LC50 (rat) = 440 mg/m3/4h
Explanatory Notes
VP from ChemIDplus;
Adverse Effects
Toxic Pneumonitis
Yes
Methemoglobinemia
MetHgb is secondary toxic effect
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Nephrotoxin
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.