1,1,1-Trifluoro-2,2-dichloroethane

Synonyms

2,2-Dichloro-1,1,1-trifluoroethane; CFC-123; Chlorofluorocarbon 123; Dichloro(trifluoromethyl)methane; FC 123; Freon 123; HCFC 123; HFA 123; Hydrochlorofluorocarbon; R 123; Refrigerant HCFC-123; Refrigerant R 123; Solkane 123; Ethane, 2,2-dichloro-1,1,1-trifluoro-; Dichlorotrifluoroethane; [ChemIDplus] SUVA 123; [MSDSonline]

Category

Chlorofluorocarbons

Description

Colorless liquid; [ICSC]

Sources/Uses

Used as a refrigerant in air conditioners, a fire extinguisher, a foam blowing agent, and a metal cleaner; [HSDB] Developed as a chlorofluorocarbon replacement; [AIHA]

Comments

An eye irritant; Can cause liver injury, narcosis, and cardiac arrhythmias; [ICSC] Effects in high-dose animal studies include anesthesia; [MSDSonline] Several clusters of occupational hepatitis have been reported, e.g., after HCFC-123 leaked in an air-conditioning system in a crane cabin and after HCFC-123 was used as a degreaser; [AIHA]

Biomedical References

718 mm Hg

LC50 (rat) = 32,000 ppm/4h

Explanatory Notes

VP from ChemIDplus;

Insufficient data

1,000 ppm

10,000 ppm

50 ppm

Acute solvent syndrome

Occupational hepatotoxin (principal effect)

Diseases

Occupational diseases associated with exposure to this agent:

• Hepatitis, chemical
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Degreasing