1,2-Dimethoxyethane

Agent Name
1,2-Dimethoxyethane
Alternative Name
Ethylene glycol dimethyl ether
CAS Number
110-71-4
Formula
C4-H10-O2
Major Category
Solvents
1,2-Dimethoxyethane formula graphical representation
Synonyms
1,2-Ethanediol dimethyl ether; 2,5-Dioxahexane; Ansul ether 121; DME (glycol ether); Dimethyl Cellosolve; Dimethylcellosolve; EGDME; Ethane, 1,2-dimethoxy-; Ethylene dimethyl ether; Ethylene glycol dimethyl ether; Glycol dimethyl ether; Glyme; Hisolve MMM; Monoethylene glycol dimethyl ether; Monoglyme; [ChemIDplus] UN2252
Category
Glycol Ethers (Glymes)
Description
Colorless liquid; [ICSC] Ether-like odor; [Merck Index] Fully miscible; [MSDSonline]
Sources/Uses
Used as a specialty solvent and reagent; [Merck Index] Used in lithium batteries and industrial coatings; [EPA: Initial Risk-Based Prioritization of HPV Chemicals: Monoglyme]
Comments
2-Methoxyethanol is a major metaobolite; "The potential health hazard of monoglyme is high based on the results of repeated-dose (blood, thymus, adrenal gland, and testicular degeneration) and developmental (increased fetal death and skeletal effects and decreased fetal body weight) toxicity studies at relatively low doses in animal studies." [EPA: Initial Risk-Based Prioritization of HPV Chemicals: Monoglyme] Reproductive toxin in animal tests; [ICSC] Labeled as "May impair fertility" and "May cause harm to the unborn child" by EU regulations; [Glycol Ethers Online] Inhalation of vapor may cause dizziness or difficulty breathing; [HSDB] A severe skin and eye irritant; [CAMEO] Reproductive toxin and highly flammable; [MSDSonline] See "GLYCOL ETHERS." See "2-Methoxyethanol."
Biomedical References

Exposure Assessment

Skin Designation (ACGIH)
Yes
Vapor Pressure
48 mm Hg
Lethal Concentration
LCLo (rat) = 17,096 ppm/6h
Explanatory Notes
Flash point = -2 deg C; [ICSC] VP from ChemIDplus; See 2023 "Notice of Intended Changes" for TLV; [ACGIH TLVs and BEIs]

Adverse Effects

Neurotoxin
Acute solvent syndrome
Reproductive Toxin
Yes

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: