Hexachlorophene

Synonyms

2,2',3,3',5,5'-Hexachloro-6,6'-dihydroxydiphenylmethane; 2,2'-Dihydroxy-3,3',5,5',6,6'-hexachlorodiphenylmethane; 2,2'-Dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane; 2,2'-Methylenebis(3,4,6-trichlorophenol); AT 7; Acigena; Almederm; Armohex; At-17; B & b Flea Kontroller for Dogs Only; B 32 (VAN); B32; Bilevon; Bis(2-hydroxy-3,5,6-trichlorophenyl)methane; Bis(3,5,6-trichloro-2-hydroxyphenyl)methane; Bis-2,3,5-trichloro-6-hydroxyfenylmethan [Czech]; Blockade Anti Bacterial Finish; Brevity Blue Liquid Bacteriostatic Scouring Cream; Brevity Blue Liquid Sanitizing Scouring Cream; Compound G-11; Cotofilm; Dermadex; Distodin; En-Viron D Concentrated Phenolic Disinfectant; Enditch Pet Shampoo; Esaclorofene [DCIT]; Exofene; Fesia-sin; Fomac; Fostril; G-11; G-Eleven; G-II; Gamophen; Gamophene; Germa-medica; HCP; Hexabalm; Hexachlorofen; Hexachlorofen [Czech]; Hexachlorophen; Hexachlorophene; Hexachlorophenum [INN-Latin]; Hexaclorofeno [INN-Spanish]; Hexafen; Hexaphene-LV; Hexide; Hexophene; Hexosan; Hilo Cat Flea Powder; Hilo Flea Powder; Methane, bis(2,3,5-trichloro-6-hydroxyphenyl)-; Nabac; Nabac 25 EC; Neosept V; Pedigree Dog Shampoo Bar; Phenol, 2,2'-methylenebis(3,4,6-trichloro)-; Phenol, 2,2'-methylenebis(3,4,6-trichloro-; Phenol, 2,2'-methylenebis(3,5,6-trichloro-; Phisodan; Ritosept; Septisol; Septofen; Solu-Heks; Staphene O; Ster-Zac; Steral; Steraskin; Surgi-Cen; Surgi-cin; Surofene; Tersaseptic; Thera-Groom Pet Shampoo for Dogs for Veterinary Use Only; Trichlorophene; Trisophen; Turgex; pHisoHex; [ChemIDplus] UN2875

Category

Biocides/Disinfectants

Description

White to light tan, crystalline powder; [HSDB]

Sources/Uses

Used as an antibacterial agent, disinfectant, fungicide, and acaricide; [HSDB]

Comments

Hexachlorophene was removed from the over-the-counter market in the 1970s after neurotoxic effects were reported. Studies showed that between 0.3% and 6% of photo patch tested patients were allergic to this substance. [Marks, p. 232-3] Asthma reported in hospital employee; [Malo] In high-dose animal studies, hexachlorophene causes testicular damage and birth defects. [Frazier, p. 271-2] Acute exposure may cause CNS effects; A skin sensitizer; May cause asthma; [ICSC]

Biomedical References

8.3E-11 mm Hg

LC50 (rat) = 340 mg/m3

Explanatory Notes

VP from HSDB;

Reference Link #2

Yes

Yes

Other CNS neurotoxin

Yes

Not classifiable

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Using Disinfectants or Biocides