Chlorhexidine acetate
Agent Name
Chlorhexidine acetate
CAS Number
56-95-1
Formula
C22-H30-Cl2-N10.2C2-H4-O2
Major Category
Other Uses
Synonyms
2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, diacetate; N,N''-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradeca- nediimidamide, diacetate; 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide) diacetate; 1,1'-Hexamethylenebis(5-(p-chlorophenyl)biguanide) diacetate; 1,6-Bis(5-(p-chlorophenyl)biguandino)hexane diacetate; 1,6-Bis(p-chlorophenylbiguanido)hexane diacetate; 1,6-Di(4'-chlorophenyldiguanidino)hexane diacetate; 10,040 Diacetate; Bactigras; Bis(p-chlorophenyldiguanidohexane) diacetate; Chlorhexidine acetate (VAN); Chlorhexidine diacetate; Chlorohexidine diacetate; Hibitane diacetate; Nolvasan; Biguanide, 1,1'-hexamethylenebis(5-(p-chlorophenyl)-, diacetate; Chlorhexidine di(acetate); [ChemIDplus]
Category
Biocides/Disinfectants
Description
White odorless solid; [Reference #1] White powder; [Aldrich MSDS]
Sources/Uses
Used as disinfectant for agricultural facilities (including egg, meat, and poultry processing); Also used to control viruses in some veterinary applications; Marketed as 2% soluble concentrates or liquids; [Reference #1]
Comments
A mild skin irritant; [RTECS] Chlorhexidine salts (gluconate, acetate, and dihydrochloride) are rarely sensitizing (plain and photo). [Marks, p. 229] Hepatic effects (decreased enzyme activity and histopathological changes) and minor irritation observed in female rabbits in 13-week dermal study; Severely toxic in primary eye irritation study; No evidence of developmental toxicity; [Reference #1] May cause irritation; A photosensitizer;[Aldrich MSDS] See "Chlorhexidine."
Reference Link #1
Biomedical References
Exposure Assessment
Lethal Concentration
LC50 (rat) = 300 mg/m3
Adverse Effects
Skin Sensitizer
Yes
Asthma
Yes
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
PACD (photoallergic contact dermatitis)
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: