Penicillic acid
Agent Name
Penicillic acid
CAS Number
90-65-3
Formula
C8-H10-O4
Major Category
Biological Agents
Synonyms
2,5-Hexadienoic acid, 3-methoxy-5-methyl-4-oxo-; 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid; Kyselina penicilova [Czech]; PA; Penicillic acid; gamma-Keto-beta-methoxy-delta-methylene-delta(sup alpha)-hexenoic acid; 3-Methoxy-5-methyl-4-oxohexa-2,5-dienoic acid; [ChemIDplus]
Category
Mycotoxins
Description
Solid; [Merck Index]
Sources/Uses
A toxic metabolite of Penicillium fungi used to make mold-ripened cheeses; [Reference #1] An antibiotic mycotoxin produced by several Penicillium and Aspergillus fungi; [Merck Index] Exhibits antiviral, antitumor, and cytotoxic activities; [HSDB]
Comments
Mycotoxin with antibiotic and carcinogenic properties; Has been found in tobacco, sausages, and corn; [ChemIDplus] Dermal application to rabbits causes severe edema and necrosis within 2 hours; A single intraperitoneal dose of 90 mg/kg decreases hepatic glutathione levels by 83%; Inhibits sodium-potassium ATPase activity in mice brain and kidney in vitro and in vivo; [HSDB] Causes other liver changes in intraperitoneal lethal-dose study of rats; [RTECS] May cause irritation; Harmful by ingestion; Targets the liver; [Aldrich MSDS]
Reference Link #1
Biomedical References
Exposure Assessment
Vapor Pressure
0.00124 mm Hg
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
IARC Carcinogen
Not classifiable
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.