All lead compound are linked to 223  (Lead Poisoning) and are also linked to a neurological disease, either 310 (Acute Toxic Encephalopathy) for organic lead compounds or 333 (Toxic Neuropathy) for other lead compounds. Organic lead compounds are also linked to 226 (Acute Hemolytic Anemia). All lead compounds are also linked to the Adverse Effects: Secondary Hepatotoxin, Reproductive Toxin, and Nephrotoxin.

 

Lead: 223, 226, 307, 333, 655, 656

Lead chromate: 223, 333

Lead arsenate: 223, 333

Lead IV oxide: 223, 333

Lead II sulfate: 223, 333

Lead II nitrate: 223, 333

Tetraethyl lead: 223, 226, 310 (Deleted 307)

Tetramethyl lead: 223, 226, 310 (Deleted 307)

Lead azide: 223, 333

Lead II thiocyanate: 223, 333

Lead nitroresorcinate: 223, 333

Lead styphate: 223, 333

Lead II acetate trihydrate: 223, 333

 

Changes Made in Review of "Health Hazard Summaries

 for Industrial and Occupational Chemicals" [Olson, Table IV-4]

 

Benzonitrile: 160, delete 351

Bromine pentafluoride: 247

p-Dichlorobenzene: 310

2-Diethylaminoethanol: 18

Dinitro-o-cresol: 160

Dinitrophenol: 160

4,6-Dinitro-o-sec-butyl phenol: 160

Dinocap: 160

2.4-Dinitrophenol:160

Diglycidyl ether: 18, 306

Epichlorohydrin: 306

Ethylene dichloride: delete 306

Ethyl silicate: 326

Furfural: 310

Glycidol: delete 18

Iodine: 306

Oxalic acid: 306

Oxygen difluoride: 247

Mercury, elemental: delete 18

Petroleum gas (liquified): 326

Propylene oxide: 306, 310

Methylamine: 306

Sodium azide: 306

Styrene: delete 18

Tellurium and compounds: 310

 

Additions Made in Review of Kidney Diseases

 

1,4-Dioxane: 656

Arsine: 656

Cadmium and compounds: 656, 655

Carbon tetrachloride: 656

Chromium and compounds: 656

Dinitro-o-cresol: 656

Dinitrophenol: 656

Diquat: 656

Lead: 656, 655

Mercury, elemental: 655

Paraquat dichloride: 656

Pentachlorophenol: 656

Stibine: 656

Uranium and compounds: 656

 

Review of 663 Chemicals Added to Haz-Map Sometime in the 1990s

Completed March 8, 2008

New Links Added to Group I (First 110 Chemicals)

Acrylic acid: 306

Hexachloroethane: 310

Nitric oxide: 306

New Links Added to Group II (Second 110 Chemicals)

Boron trifluoride: 247

Bromine pentafluoride: 247

n-Butane: 350

tert-Butyl chromate: 310

Camphor, synthetic: 310

Caprolactam: 310

Catechol: 310

alpha-Chloroacetophenone: 306

bis-Chloromethyl ether: 306

Chloromethyl methyl ether: 306

Chromyl chloride: 306

Vinyl bromide: 326

Vinyl fluoride: 326

Vinylidene chloride: 326

New Links Added to Group III (Third 110 Chemicals)

2-Nitropropane: 326

1,3-Dichloro-5,5-dimethylhydantoin: 306

Diethyl ketone: 325

o-Dichlorobenzene: 325

Ethyl butyl ketone: 325

Ethylidene norbornene: 326

Formamide: 326

Isobutyl acetate: 325

N-Isopropylaniline: 18

p-Toluidine: 18

Vinyl cyclohexene dioxide: 306

New Links Added to Group IV (Fourth 110 Chemicals)

Dimethylaminopropionitrile: 333

Methyl acetylene-propadiene mixture: 326; 325

Methylcyclohexanol: 325

Morpholine: 306

Nitroethane: 326

Nitrogen trifluoride: 247

1-Nitropropane: 326; 325

Nonane: 325

Oxygen difluoride: 247

Phenylphosphine: 226

Phosphoric acid: 306

Thioglycolic acid: 306

New Links Added to Group V (Fifth 110 Chemicals)

N,N-Dimethyl-1,3-propanediamine: 306

Hexachlorophene: 18; 310

p-Nitrochlorobenzene: 18

4-Nitrophenol: 18

Sodium fluoride: 247

Sulfur tetrafluoride: 247

Triethylene tetramine: 306

New Links Added to Group VI (Last 113 Chemicals)

Benzotriazole: 18

Benzylamine: 306

Bithionol: 18; 267

Boron trifluoride etherate: Delete 326

1-Bromo-2-propanol: 326

Butylated hydroxyanisole: 23

Chloramide: Delete 23

Dichlorophen: 18

Ethyl lactate: 326; 325

Ethyl-3-ethoxypropionate: 326

Fentichlor: 267

Tetramethyl ammonium hydroxide: 306

Triclosan: 18; 267

 

Change of Links to Chronic Solvent Encephalopathy (ID 325)

 

Instead of the previous rule of linking to all agents tagged with the adverse effect "Solvent Syndrome," this disease is now linked with all chemicals that are so tagged AND they are also linked to the Process "Painting (Solvents)." Any other chemicals, such as Styrene, with strong epidemiologic evidence of association with chronic solvent syndrome will also be linked to this disease. The following table shows all chemicals linked to Acute Solvent Syndrome. Chemicals that are also linked to Chronic Solvent Encephalopathy are shown in bold.

 

1,1,1,2-Tetrachloro-2,2-difluoroethane 1,1,1,2-Tetrachloroethane 1,1,1,2-Tetrafluoroethane 1,1,1-Trichloroethane 1,1,2,2-Tetrabromoethane 1,1,2,2-Tetrachloro-1,2-difluoroethane 1,1,2,2-Tetrachloroethane 1,1,2-Trichloro-1,2,2-trifluoroethane 1,1,2-Trichloroethane 1,1-Dichloroethane 1,1-Difluoroethane 1,2,3,4-Tetrahydronaphthalene 1,2,3-Trichloropropane 1,2,4,5-Tetrachlorobenzene 1,2,4-Trichlorobenzene 1,2-Dichloroethylene, all isomers 1,3-Dichloropropene 1,3-Dioxolane 1,4-Dioxane 1-Bromo-2-propanol 1-Bromopropane 1-Hexanol 1-Hexene 1-Nitropropane 2,2-Dimethylbutane 2-Butanone 2-Butoxyethanol 2-Butoxyethyl acetate 2-Ethoxyethanol 2-Ethoxyethyl acetate 2-Isopropoxyethanol 2-Methoxyethanol 2-Nitropropane 4-Vinyl cyclohexene Acetone Acetophenone Acetyl acetone Acetylene alpha-Methyl styrene Benzene Benzyl acetate Bromobenzene Bromoform Butyrolactone Carbon tetrabromide Carbon tetrachloride CHLORINATED SOLVENTS Chlorobenzene Chlorobromomethane Chlorodifluoromethane CHLOROFLUOROCARBONS Chloroform Chloropentafluoroethane Chloropropanol Chlorotrifluoromethane Collodion Cumene Cycloheptane Cyclohexane Cyclohexanol Cyclohexanone Cyclohexene Cyclopentadiene Cyclopentane Decahydronaphthalene Decanol Diacetone alcohol Diacetyl Dibromomethane Dichlorodifluoromethane Dichloroethyl ether Dichloromonofluoromethane Dichlorotetrafluoroethane Diesel fuel Diethyl ketone

Diethylene glycol dibutyl ether Diethylene glycol dimethyl ether Diethylene glycol monobutyl ether Diethylene glycol monoethyl ether Diethylene glycol monohexyl ether Diethylene glycol monophenyl ether Difluorodibromomethane Diisobutyl ketone Dimethyl acetamide Dimethyl ether Dimethyl sulfoxide Dimethylformamide Dipropyl ketone Dipropylene glycol methyl ether Divinyl benzene Dodecane Enflurane Ethane Ethyl acetate Ethyl alcohol Ethyl amyl ketone Ethyl benzene Ethyl bromide Ethyl butyl ketone Ethyl chloride Ethyl ether Ethyl formate Ethyl lactate Ethyl nitrite Ethyl silicate Ethyl tert-butyl ether Ethyl-3-ethoxypropionate Ethylene Ethylene chlorohydrin Ethylene dibromide Ethylene dichloride Ethylene glycol monophenyl ether Ethylidene norbornene Fluorotrichloromethane Fluroxene Formamide Furan Furfuryl alcohol Gasoline GLYCOL ETHERS Hexadecane Hexylene glycol Isoamyl acetate Isoamyl alcohol Isobutane Isobutyl acetate Isobutyl alcohol Isooctyl alcohol Isopentane Isophorone Isoprene Isopropyl acetate Isopropyl alcohol Isopropyl ether Jet fuel Kerosene Mesityl oxide Methoxyflurane Methyl (n-amyl) ketone Methyl acetate Methyl acetylene Methyl acetylene-propadiene mixture Methyl cellosolve acetate Methyl chloride Methyl formate Methyl isoamyl ketone Methyl isobutyl carbinol Methyl isobutyl ketone Methyl n-butyrate

Methyl propyl ketone Methyl tert-butyl ether Methyl vinyl ketone Methylal Methylcyclohexane Methylcyclohexanol Methylene chloride n-Amyl acetate Naphtha (coal tar) n-Butane n-Butyl acetate n-Butyl alcohol n-Butyl lactate Neopentane n-Heptane Nitroethane N-Methyl-2-pyrrolidone Nonadecane Nonane n-Pentane n-Propyl acetate n-Propyl alcohol n-Propylbenzene o-Chlorostyrene o-Chlorotoluene Octadecane Octane o-Dichlorobenzene o-Methylcyclohexanone ORGANIC SOLVENTS Pentachlorobenzene Pentachloroethane Pentadecane Petroleum distillates Petroleum gas (liquefied) Petroleum mid-distillate Propadiene Propane Propargyl alcohol Propyl ether Propylene dichloride Propylene glycol monomethyl ether p-tert-Butyltoluene sec-Amyl acetate sec-Butyl acetate sec-Butyl alcohol sec-Hexyl acetate Stoddard solvent Styrene tert-Amyl methyl ether tert-Butyl acetate tert-Butyl alcohol Tetrachloroethylene Tetradecane Tetrahydrofuran Toluene Trichloroethylene Tridecane Trifluorobromomethane Trifluorochloroethylene Trifluoromethane Trimethyl benzene isomers Turpentine Undecane Urethane Vinyl acetate Vinyl bromide Vinyl fluoride Vinyl methyl ether Vinyl toluene Vinylidene chloride Vinylidene fluoride VM & P Naphtha Xylene isomers

 

Chlorofluorocarbons Now Classified as Simple Asphyxiants

 

"In general, anesthetic or CNS-depressant doses require fairly large air concentrations, which can also displace oxygen, leading to asphyxia." [Freons and Halons, Olson, p. 208] "Inhalation of concentrated gas will cause suffocation." [CAMEO profile on 1,1-Difluoroethane] "On loss of containment this liquid evaporates very quickly displacing the air and causing a serious risk of suffocation when in confined areas." [ICSC profile on Dichlorodifluoromethane] The following CFCs are gases at room temperature and are now linked to "Asphyxiation, simple" (ID 350) in addition to "Solvents, acute toxic effect" (ID 326):

 

Chloropentafluoroethane	76-15-3
Dichlorodifluoromethane	75-71-8
Dichloromonofluoromethane	75-43-4
Dichlorotetrafluoroethane	76-14-2
Difluorodibromomethane	75-61-6
Trifluorobromomethane	75-63-8
1,1,1,2-Tetrafluoroethane	811-97-2
Chlorodifluoromethane	75-45-6
CHLOROFLUOROCARBONS
Trifluoromethane	75-46-7
Chlorotrifluoromethane	75-72-9
1,1-Difluoroethane	75-37-6

Delinking Two Occupational Diseases from Adverse Effects

 

The disease "Asphyxiation, chemical" is no longer linked to the Adverse Effect with the same name. This means that a chemical can be tagged as a chemical asphyxiant on the basis of ingestion poisoning, but if will not be automatically linked to the occupational disease. At this time the only chemicals linked to the occupational disease after inhalation exposure are:

Carbon monoxide

Cyanogen bromide

Cyanogen

Hydrogen sulfide

CYANIDES

Sodium cyanide

Hydrogen cyanide

Cyanogen iodide

Acetone cyanohydrin

Potassium cyanide

Cyanogen chloride

The other chemicals that were previously linked to the occupational disease are still tagged with chemical asphyxiation as a potential adverse effect. The adverse effects of chemicals refers to both occupational and non-occupational exposures. Delinked from "Asphyxiation, chemical" the disease are the following:

 

1-Butanethiol 1-Decanethiol 1-Dodecanethiol 1-Heptanethiol 1-Hexadecanethiol 1-Hexanethiol 1-Nonanethiol 1-Octadecanethiol 1-Octanethiol 1-Pentanethiol 1-Propanethiol 1-Undecanethiol 2-Methyl-2-heptanethiol Acetonitrile Acrylonitrile Adiponitrile

Ammonium thiocyanate AZIDES Calcium hydrosulfite Carbonyl sulfide Copper II azide Cyclohexanethiol Decanenitrile Ethanethiol Glycolonitrile Isobutyronitrile Lead azide Lead II thiocyanate Malononitrile Mercury azide Mercury II azide

Methyl mercaptan Methylacrylonitrile n-Butyronitrile NITRILES Potassium ferricyanide Propionitrile Silver azide Sodium azide Sodium hydrogen sulfide Sodium hydrosulfite Sodium sulfide Succinonitrile tert-Octyl mercaptan Tetramethyl succinonitrile THIOLS Zinc hydrosulfite

 

Similarly, the disease Parkinsonism is now linked to only Carbon monoxide and Manganese. Other chemicals, e.g., MPTP, are tagged with the adverse effect but are not linked to the occupational disease. Delinked from Parkinsonism are MPTP and all other manganese compounds.

 

Section 2 (Sent to NLM July 21, 2008)

 

Change of Links to Chronic Solvent Encephalopathy (ID 325)

 

The agent-disease links were further refined after doing more research on the Sources/Uses of each chemical. The following chemicals are linked to the disease because they have been used as paint solvents or otherwise linked to chronic solvent encephalopathy (e.g., styrene).

 

1,1,1,2-Tetrachloroethane 1,1,1-Trichloroethane 1,1,2,2-Tetrachloroethane 1,1,2-Trichloroethane 1,2,3,4-Tetrahydronaphthalene 1,2,3-Trichloropropane 1,2-Dichloroethylene, all isomers 1,3-Dioxolane 1,4-Dioxane 1-Bromopropane 1-Hexanol 1-Nitropropane 2-Butanone 2-Butoxyethanol 2-Butoxyethyl acetate 2-Ethoxyethanol 2-Ethoxyethyl acetate 2-Ethylhexanoic acid 2-Isopropoxyethanol 2-Methoxyethanol 2-Nitropropane Acetone Acetyl acetone Benzonitrile Benzyl acetate Carbon tetrachloride Chlorobenzene Cumene Cyclohexane Cyclohexanol Cyclohexanone Cyclopentane Decahydronaphthalene Diacetone alcohol Diethyl ketone Diethylene glycol dibutyl ether Diethylene glycol monobuty l ether

Diethylene glycol monoethyl ether Diethylene glycol monohexyl ether Diisobutyl ketone Dimethylformamide Dipropyl ketone Dipropylene glycol methyl ether Ethyl acetate Ethyl alcohol Ethyl benzene Ethyl butyl ketone Ethyl lactate Ethylene glycol GLYCOL ETHERS Isoamyl acetate Isoamyl alcohol Isobutyl acetate Isobutyl alcohol Isophorone Isopropyl acetate Isopropyl alcohol Isopropyl ether Kerosene Mesityl oxide Methyl (n-amyl) ketone Methyl acetate Methyl alcohol Methyl isoamyl ketone Methyl isobutyl carbinol Methyl isobutyl ketone Methyl n-butyrate Methyl propyl ketone Methylal Methylcyclohexanol Methylene chloride n-Amyl acetate Naphtha (coal tar)

n-Butyl acetate n-Butyl alcohol n-Butyl lactate N-Methyl-2-pyrrolidone Nonane n-Propyl acetate n-Propyl alcohol o-Chlorotoluene o-Dichlorobenzene o-Methylcyclohexanone ORGANIC SOLVENTS Petroleum distillates Propylene glycol Propylene glycol monomethyl ether Pyridine sec-Amyl acetate sec-Butyl acetate sec-Butyl alcohol sec-Hexyl acetate Stoddard solvent Styrene tert-Butyl acetate tert-Butyl alcohol Tetrahydrofuran Toluene Trichloroethylene Turpentine VM & P Naphtha Xylene isomers

 

The following chemicals were delinked from the disease Chronic Solvent Encephalopathy:

1,1,1,2-Tetrachloro-2,2-difluoroethane 1,1,1,2-Tetrafluoroethane 1,1,2,2-Tetrabromoethane 1,1,2,2-Tetrachloro-1,2-difluoroethane 1,1,2-Trichloro-1,2,2-trifluoroethane 1,1-Dichloroethane 1,1-Difluoroethane 1,2,4,5-Tetrachlorobenzene 1,2,4-Trichlorobenzene 1,3-Dichloropropene 1-Bromo-2-propanol 1-Hexene 2,2-Dimethylbutane 4-Vinyl cyclohexene Acetophenone Acetylene alpha-Methyl styrene Bromobenzene Bromoform Butyrolactone Carbon tetrabromide Chlorobromomethane Chlorodifluoromethane CHLOROFLUOROCARBONS Chloroform Chloropentafluoroethane Chloropropanol Chlorotrifluoromethane Collodion Cycloheptane Cyclohexene Cyclopentadiene Decanol Diacetyl Dibromomethane Dichlorodifluoromethane Dichloroethyl ether Dichloromonofluoromethane Dichlorotetrafluoroethane Diesel fuel Diethylene glycol dimethyl ether Diethylene glycol monophenyl ether Difluorodibromomethane

Dimethyl acetamide Dimethyl ether Dimethyl sulfoxide Divinyl benzene Dodecane Enflurane Ethane Ethyl amyl ketone Ethyl bromide Ethyl butyl ketone Ethyl chloride Ethyl ether Ethyl formate Ethyl nitrite Ethyl silicate Ethyl tert-butyl ether Ethyl-3-ethoxypropionate Ethylene Ethylene chlorohydrin Ethylene dibromide Ethylene dichloride Ethylene glycol monophenyl ether Ethylidene norbornene Fluorotrichloromethane Fluroxene Formamide Furan Furfuryl alcohol Gasoline Hexadecane Hexylene glycol Isobutane Isobutyl acetate Isobutyl alcohol Isooctyl alcohol Isopentane Isoprene Jet fuel Methoxyflurane Methyl acetylene Methyl acetylene-propadiene mixture Methyl cellosolve acetate Methyl chloride

Methyl formate Methyl tert-butyl ether Methyl vinyl ketone Methylcyclohexane n-Butane Neopentane n-Heptane Nitroethane Nonadecane n-Pentane n-Propylbenzene o-Chlorostyrene Octadecane Octane Pentachlorobenzene Pentachloroethane Pentadecane Petroleum gas (liquefied) Petroleum mid-distillate Propadiene Propane Propargyl alcohol Propyl ether Propylene dichloride p-tert-Butyltoluene tert-Amyl methyl ether Tetrachloroethylene Tetradecane Tridecane Trifluorobromomethane Trifluorochloroethylene Trifluoromethane Trimethyl benzene isomers Undecane Urethane Vinyl acetate Vinyl bromide Vinyl fluoride Vinyl methyl ether Vinyl toluene Vinylidene chloride Vinylidene fluoride

 

Changes in the Links to Acute Toxic Encephalopathy (ID 310)

 

Acute toxic encephalopathy was delinked from the adverse effect "Other CNS Neurotoxin." In the following list, all of these chemicals will continue to be linked to that adverse effect, but only the ones in bold will be linked to the occupational disease Acute Toxic Encephalopathy. The underlined chemicals are linked to the disease "Fumigants, acute toxic effect."

1,1-Dimethylhydrazine 1,2-Dimethylhydrazine 1,3-Butadiene 2-Aminopyridine 4-Aminopyridine Allethrin Aluminum phosphide Benzotrichloride Benzyl chloride beta-Chloroprene Biphenyl Bismuth Boric acid Calcium phosphide Camphor, synthetic Caprolactam Catechol Cyclonite Cypermethrin Decaborane DEET Dimethyl disulfide Dimethyl sulfide Dimethylmercury Fenvalerate Fipronil

Furfural Hexachloroethane Hexachlorophene Hydrazine Hydrazine mononitrate Imiprothrin Iron pentacarbonyl Manganese cyclopentadienyl tricarbonyl Mercury, alkyl compounds Mercury, aryl compounds Methanesulfonic acid Methyl alcohol Methyl bromide Methyl iodide Methyl isothiocyanate Methylcyclopentadienyl manganese tricarbonyl Methylhydrazine Nickel carbonyl Nicotine Nitrogen mustard (HN-1) Nitrogen mustard (HN-2) Nitrogen mustard (HN-3) Nitromethane p-Dichlorobenzene Pentaborane Phenol

Phenothrin Phenylmercuric acetate PHOSPHIDES Phosphine Propylene oxide Pyrethrum Pyridine Pyrrolidine Quinuclidinyl benzilate Radiation, ionizing Rotenone Sodium borohydride Sodium fluoroacetate Strychnine Sulfuryl fluoride Tellurium and compounds tert-Butyl chromate Tetraethyl lead Tetramethrin Tetramethyl lead Tin, organic compounds Triallylamine Triisobutylaluminum Xenon Zinc phosphide

The name of Alizarin yellow (584-42-9) was changed to Alizarine yellow G. This chemical will be published with the next batch of 184 chemicals, ie, not yet sent to NLM.

The name of Acid alizarin violet N (2092-55-9) was changed to Alizarine violet N. This chemical was sent to NLM in the last batch and is due to be published in June.

Difluorodibromomethane (75-61-6) was linked to the disease Pneurmonitis, toxic.

Mapping Rules for Pb, Mn, Hg, and Cr Compounds

The rule for lead compounds has been changed. Except for "Lead" itself, Inorganic lead compounds are no longer linked to Toxic neuropathy (333). The following list, copied from above, shows the linked diseases that have been removed (red font:

Lead: 223, 226, 307, 333, 655, 656

Lead chromate: 223, 333

Lead arsenate: 223, 333

Lead IV oxide: 223, 333

Lead II sulfate: 223, 333

Lead II nitrate: 223, 333

Tetraethyl lead: 223, 310, 226

Tetramethyl lead: 223, 310, 226

Lead azide: 223, 333

Lead II thiocyanate: 223, 333

Lead nitroresorcinate: 223, 333

Lead styphate: 223, 333

Lead II acetate trihydrate: 223, 333

 

All lead compound are linked to 223  (Lead Poisoning). All lead compounds are also linked to the Adverse Effects:  Motor Neuropathy, Reproductive Toxin, Nephrotoxin, and Hemolytic Anemia..

All inorganic manganese compounds are linked to the Adverse Effect Parkinsonism and to the Disease Manganese, chronic toxic effect (239).

All inorganic mercury compounds are linked to the Adverse Effects Nephrotoxin.and Sensorimotor Neuropathy.

All inorganic chromium compounds are linked to the Disease Chromium, chronic toxic effect (17).

 

Delinking Adverse Effects from Disease Toxic Neuropathy

The following list of chemicals are linked to one of the Adverse Effects, either motor neuropathy or sensorimotor neuropathy:

Motor Neuropathy

Sensorimotor Neuropathy

Chlorpyrifos Dichlorvos EPN 1. n-Hexane 2-Hexanone 2. Lead Lead azide Lead chromate Lead II acetate trihydrate Lead II nitrate Lead II sulfate Lead II thiocyanate Lead IV oxide Lead nitroresorcinate Lead styphnate Leptophos Mercury II fulminate Methamidophos Mipafox Omethoate 3. ORGANOPHOSPHATES Parathion Trichlorfon Trichloronate Triorthocresyl phosphate

4. Acrylamide Allyl chloride 5. Arsenic and compounds Arsenic trichloride Calcium arsenate 6. Carbon disulfide Dichloroacetylene Dimethylaminopropionitrile 7. Ethylene oxide Gallium arsenide Lead arsenate Mercuric chloride Mercuric nitrate Mercurous nitrate 8. Mercury, elemental Mercury II acetate 9. Mercury, inorganic compounds Nitrous oxide Phenyl arsine oxide 10. Thallium and soluble compounds Thallous nitrate

 The agents that are not numbered have been delinked from the occupational disease Neuropathy, toxic. The numbered chemicals continue to be linked to that disease.

Delinking Adverse Effects from Disease Lung Cancer

The following list of chemicals are linked to the Adverse Effect Lung cancer:

Arsenic and compounds Arsenic trichloride Asbestos Beryllium and compounds Bis(2-chloroethyl)sulfide bis-Chloromethyl ether Cadmium and compounds Calcium arsenate Calcium chromate Chloromethyl methyl ether

Chromic acid and chromates Chromium and compounds Chromium trioxide Chromyl chloride Coke oven emissions Lead arsenate Lead chromate Nickel and compounds Nickel carbonyl Phenyl arsine oxide

Plutonium Potassium dichromate Radiation, ionizing Radon Silica, crystalline Soots Strontium chromate tert-Butyl chromate Zinc chromates

The agents that are not underlined have been delinked from the occupational disease Lung cancer. The underlined chemicals continue to be linked to that disease.

Delinking Adverse Effects from Disease Aplastic Anemia

The following list of chemicals are linked to the Adverse Effect Aplastic Anemia:

Benzene 2-Methoxyethanol Heptachlor Lindane 2,4,5-Trinitrotoluene Glycol ethers

Calcium arsenate Arsenic and compounds Diethylene glycol monobutyl ether beta-Hexachlorocyclohexane Nitrogen mustard (HN-2) Nitrogen mustard (HN-3)

Arsenic trichloride Lead arsenate Nitrogen mustard (HN-1) Radiation, ionizing Phenyl arsine oxide

The agents that are not underlined have been delinked from the occupational disease Aplastic Anemia. The underlined chemicals continue to be linked to that disease.

Delinking Adverse Effects from Disease Hemolytic Anemia

The following list of chemicals are linked to the Adverse Effect Hemolytic Anemia.

Lead Stibine Arsine Phenylhydrazine Tetraethyl lead

Tetramethyl lead Dieldrin Germanium tetrahydride Phenylphosphine

Trimellitic anhydride CHLORATES Lewisite Potassium chlorate

The agents that are not underlined have been delinked from the occupational disease Hemolytic Anemia. The underlined chemicals continue to be linked to that disease.

Insufficient Data

In current batch of 183 chemicals, the following were moved to the "Insufficient Data" table: Nickel hypophosphite, Dirhodium octacarbonyl, Malachite green hydrochloride, and Coomassie blue. 

Name Changes

Of the remaining 179 chemicals, the following name changes were made: Food red No. 3 to Erythrosine sodium and D & C red no. 17 to Sudan III. Name changes were also made to four previously published chemicals. In all cases the "no." was removed from the name: FD&C blue 1, FD&C blue 2, FD&C red 40, and FD&C yellow 6. Propylene imine was changed to Propyleneimine.

Male Reproductive Toxins

Linked to Disease 307 (Infertility, Male) were the following chemicals:

 

1. Carbon disulfide	5. GLYCOL ETHERS	Lead II thiocyanate
2. Manganese	6. 1,2-Dibromo-3-chloropropane	Lead azide
3. Lead	7. Chlordecone	Manganese tetroxide
4. 2-Bromopropane	Manganese dioxide	beta-Chloroprene

The first seven chemicals continue to be linked to this disease. The remaining five chemicals are no longer linked to this disease.

New Agent-Disease Links 7/21/08

 

Molybdate orange	17, 223
Chromium hexacarbonyl	17
Dimanganese decacarbonyl	239
1,2,3,4-Tetramethylbenzene	326
2-Decanone	326
Chromium carbide	17
Chromium II chloride	17
Chromium II fluoride	17, 247
Chromium III perchlorate	17
Chromium II sulfate	17
Chromium III acetylacetonate	17
Chromium III bromide	17
Chromium III chloride hexahydrate	17
Chromium III chloride	17
Chromium III fluoride hydrate	17, 247
Chromium III nitrate nonahydrate	17
Chromium III oxide	17
Chromium III phosphate	17
Chromium III sulfate	17
Chromium III sulfide	17
Chromium potassium sulfate dodecahydrate	17
Chromium potassium sulfate	17
Chromium silicide	17
Chromium trihydroxide	17
Chromyl fluoride	17, 247
Lead bis(2-ethylhexanoate)	223
Lead fluoride	223
Lead fluoroborate	223
Lead II acetate	223
Lead II bromide	223
Lead II carbonate	223
Lead II chloride	223
Lead II citrate	223
Lead II hydroxide	223
Lead II iodide	223
Lead II oxalate	223
Lead II oxide	223
Lead II perchlorate	223
Lead II phosphate	223
Lead II selenate	223
Lead II selenide	223
Lead II stearate	223
Lead II sulfide	223
Lead II sulfite	223
Lead II telluride	223
Lead III oxide	223
Lead IV acetate	223
Lead metasilicate	223
Lead molybdate	223
Lead niobium oxide	223
Lead octoate	223
Lead orthosilicate	223
Lead subacetate	223
Lead tantalate	223
Lead tetraoxide	223
Lead titanate	223
Lead tungstate	223
Lead vanadate	223
Lead zirconate titanate	223
Lead zirconate	223
Manganese II acetate	239
Manganese II carbonate	239
Manganese II chloride	239
Manganese II fluoride	239
Manganese II molybdate	239
Manganese II oxide	239
Manganese II sulfate	239
Manganese II sulfide	239
Manganese III fluoride	239
Manganese III oxide	239
Manganese, bis(eta5-cyclopentadienyl)	239
Nickel bis(2-ethylhexanoate)	18
Nickel biscyclopentadiene	18
Nickel boride	18
Nickel II acetate	18, 23
Nickel II carbonate	18, 23
Nickel II chloride	18, 23
Nickel II hydroxide	18, 23
Nickel II oxide	18, 23
Nickel II perchlorate hexahydrate	18
Nickel II phthalocyanine	18
Nickel II stearate	18
Nickel II sulfamate	18
Nickel II sulfate heptahydrate	18
Nickel II sulfide	18, 23
Nickel III oxide	18, 23
Nickel IV oxide	18, 23
Nickel naphthenate	18
Nickel potassium cyanide	18
Nickel telluride	18
Trinickel disulfide	18, 23, 306
2-Bromopropane	326
ORGANOMETALS	306

 

Section 3 (Sent to NLM October 18, 2008)

 

Recent evidence shows that 1-Bromopropane and 2-Bromopropane cause toxic neuropathy in high-dose animal studies, and 1-Bromopropane causes occupational neuropathy. [Matsuoka M. Neurotoxicity of organic solvents--recent findings. Brain Nerve 2007 Jun;59(6):591-6] Both chemicals are being used as replacements for chlorofluorocarbons. 2-Bromopropane was found to be a reproductive toxin, so it was replaced with 1-Bromopropane. 1-Bromopropane is less toxic to the reproductive system but more toxic to peripheral nerves. [Ichihara G et al. Neurological Abnormalities in Workers of a 1-Bromopropane Factory. Environ Health Perspect. 2004 Sep;112(13):1319-25] 1-Bromopropane is now linked to Toxic neuropathy (333). Both chemicals are linked to acute solvent syndrome (326), and 1-Bromopropane is also linked to Chronic encephalopathy (325). 1-Bromopropane has an ACGIH TLV. 2-Bromopropane was sent to NLM in the last batch with the "z" chemicals. 2-Bromopropane is also linked to 307 (Infertility, Male). Like n-Hexane, 1-Bromopropane is a solvent that causes occupational neuropathy. n-Hexane is now linked to the same diseases as 1-Bromopropane: 333, 326, and 325. 

 

Linked to Occupational asthma: Sodium persulfate and Potassium persulfate;

The disease "Hypersensitivity pneumonitis, chronic" was renamed "Hypersensitivity pneumonitis."

The disease "Sinusitis" was renamed "Rhinitis, occupational."

 

Mapping Rules for Inorganic Fluoride Compounds

The following inorganic fluoride compounds are linked to the occupational disease, Skeletal fluorosis: 

Fluorides, inorganic;

Sodium aluminum fluoride; and

Calcium fluoride.

All solid inorganic fluoride compounds will be given the generic occupational exposure levels (OELs) for "Fluorides, inorganic": 

TLV: 2.5 mg/m3, as F;

PEL: 2.5 mg/m3, as F;

MAK: 1 mg/m3, as F (inhalable fraction);

IDLH 250 mg/m3, as F;

BEI: Fluorides in urine = 3 mg/g creatinine prior to shift or 10 mg/g creatinine at end of shift;

Exceptions are radioactive compounds and those with a TLV, PEL, or MAK value assigned for toxicity other than fluorosis.

The following chemicals are no longer linked to the occupational disease, Skeletal fluorosis:

Antimony pentafluoride

Boron trifluoride

Bromine pentafluoride

Carbonyl fluoride

Nitrogen trifluoride

Oxygen difluoride

Perchloryl fluoride

Sulfur tetrafluoride

Fluorosilicic acid

Nickel II fluoride

Silicon tetrafluoride

Ammonium bifluoride

Chromium II fluoride

Chromium III fluoride hydrate

Chromyl fluoride

Lead fluoride

Manganese II fluoride

Manganese III fluoride

Sodium fluoride

 

Addendum to Chemical Asphyxiants

The following agents which are currently linked to chemical asphyxiation as an Adverse Effect will also be linked to chemical asphyxiation as an Occupational Disease:

1-Butanethiol

Tetramethyl succinonitrile

Acetonitrile

Acrylonitrile

NITRILES

THIOLS

 

Section 4 (Published by NLM January 15, 2009)

 

Tetrakis (hydroxymethyl) phosphonium salts was deleted and replaced with Tetrakis (hydroxymethyl) phosphonium chloride and Tetrakis (hydroxymethyl) phosphonium sulfate.

 

"Pneumonitis, toxic" was linked to the agent "Indium and compounds."

 

Section 5 (Published by NLM 06/29/09)

Delinking Adverse Effects from the Disease Toxic Pneumonitis

There are now 417 chemicals tagged with the adverse effect Pneumonitis. This includes chemicals that have not yet been published on the NLM website. In the past, all chemicals with the adverse effect were automatically linked to the disease "Pneumonitis, toxic." With this revision, only 116 chemicals are linked to the occupational disease. The main criteria for selecting those chemicals to link to the disease was whether or not the chemical is designated as a toxic inhalation hazard (TIH) in ERG 2008. The following was added to the comments field for the disease "Pneumonitis, toxic."

In this database, agents linked to toxic pneumonitis are divided into two categories: primary and secondary. The primary chemicals are listed as toxic inhalation hazards (TIH) in the 2008 Emergency Response Guidebook. These chemicals are linked to the occupational disease "Pneumonitis, toxic." The secondary chemicals are not linked to the occupational disease, but they are tagged with "Pneumonitis" as an adverse effect. Because of their importance in work-related exposures, chlorine dioxide, cadmium fume, ozone, and elemental mercury vapor are also linked to the occupational disease even though they are not designated TIH.

Section 6 (Published by NLM September 14, 2009)

Deleted Agent-Disease links for the following:

Ethylphenyldichlorosilane (ID #1482) is no longer linked to Pneumonitis, toxic;

Ethyl benzoate (ID # 8255) is no longer linked to Encephalopathy, chronic toxic;

Methyl carbamate (ID# 6075) is no longer linked to Solvents, acute toxic effect;

 

1,1,1-Trifluoro-2,2-dichloroethane (ID# 7876) was linked to Hepatitis, toxic.

Propylene glycol (ID# 685) was linked to Solvents, acute toxic effect;

Benzyl alcohol (ID# 1267) was linked to Solvents, acute toxic effect;

p-Aminobenzoic acid (ID# 3473) was linked to Contact dermatitis, allergic and Contact dermatitis, photoallergic;

2,4-Dichlorophenol (ID# 3006) was linked to Pentachlorophenol/Dinitrophenol, acute;

 

Deleted the Agent: "DYES."

Added "Octene" to the M Chemicals.

 

Deleted from Haz-Map and Added to Insufficient Data Table:

Zirconium tritide (ID 8499)

Zirconium titanate (ID 8498)

Zirconium tetraborohydride (ID 8497)

Zirconium octaethylporphine (ID 8489)

Zirconium III chloride (ID8476)

Zirconium cyanonitride (ID 8468)

Cadmium tungstoborate (ID 8441)

 

Moved from Insufficient Data Table to the New M Group in Haz-Map

Curium oxide (ID 1713)

Dicesium hexachloroplutonate (ID 1714)

Plutonium nitrate (ID 1720)

Thorium oxalate (ID 1737)

Tritium oxide (ID 1740)

Uranium trifluoride (ID 1751)

Neptunium oxide (ID 1803)

Plutonium difluoride (ID 1804)

Polonium tetranitrate (ID 1812)

Thorium carbide (ID 1817)

Coumarin 445 (ID 2174)

 

Added to 1-Nitronaphthalene (ID 2909) a link to "Methemoglobinemia, acute";

Changed name of 1,1"-Oxybisoctane (ID 8507) to Dioctyl ether;

Added to 2-Hexanone (ID 145) a link to "Neuropathy, toxic";

Deleted links to the disease "Raynaud, phenomenon of" for the following:

Calcium arsenate (ID 757), Arsenic trichloride (ID 1565), and Lead arsenate (ID 1656);

Changed "Raynaud, phenomenon of" to "Raynaud's phenomenon";

Changed "Coal workers, pneumoconiosis of" to "Coal workers' pneumoconiosis";

 

21 May 09 Review of Chromium Compounds: Diseases Added or Deleted

Added to Chromium dioxide (2029): Chromium, chronic toxic effect (17); asthma (23); and allergic contact dermatitis (18);

Deleted Chromium, chronic toxic effect (17) for the following: 

Chromium hexacarbonyl (2453)

Chromium carbide (2493)

Chromium II chloride (2495)

Chromium II fluoride (2496)

Chromium III perchlorate (2497)

Chromium II sulfate (2498)

Chromium III actylacetonate (2499)

Chromium III bromide (2500)

Chromium III chloride hexahydrate (2501)

Chromium III chloride (2502)

Chromium III fluoride tetrahydrate (2503)

Chromium III nitrate nonahydrate (2504)

Chromium III oxide (2505)

Chromium III phosphate (2506)

Chromium III sulfate (2507)

Chromium III sulfide (2508)

Chromium potassium sulfate dodecahydrate (2509)

Chromium potassium sulfate (2510)

Chromium silicide (2511)

Chromium trihydroxide (2512)

 

Deleted "Contact dermatitis, allergic" as a link to "Arsenic and compounds."

Added "Manganism" as a synonym of "Parkinsonism."

 

Beryllium and compounds linked to the disease "Contact dermatitis, allergic";

"Arsenic and compounds" changed to "Arsenic and inorganic compounds";

Dibutyl phenylphosphate (ID 2623) changed to Dibutyl phenyl phosphate;

Deleted CAS # 26249-20-7 for 1,2-Epoxybutane (ID 6481);

Deleted CAS # 961-11-5 of Tetrachlorvinphos (ID 7341)

Deleted CAS # 12655-93-5 for Nobium hydride (ID 3295)

Deleted CAS # 12648-43-0 for Palladium sulfide (ID 8304)

Changed CAS # to 123333-98-2 for Chromium III fluoride tetrahydrate (ID 2503);

 

Section 7 (Published by NLM September 14, 2009)

Deleted Agent-Disease link for Phenyl arsine oxide and Raynaud's phenomenon;

Deleted Agent-Disease link for Diepoxybutane and Pneumonitis, toxic;

Sodium arsenate linked to the disease "Contact dermatitis, allergic";

"Mercury, aryl compounds" linked to "Neuropathy, toxic"; 

Revised: June 27, 2019

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