2-Chloroaniline

Synonyms

1-Amino-2-chlorobenzene; 2-Chloroaniline; 2-Chlorobenzenamine; 2-Chlorophenylamine; Aniline, o-chloro-; Benzenamine, 2-chloro-; Fast Yellow GC Base; o-Aminochlorobenzene; o-Chloraniline; o-Chloroaminobenzene; o-Chloroaniline; [ChemIDplus] UN2019

Category

Amines, Aromatic

Description

Clear amber liquid with an amine odor; [CAMEO]

Sources/Uses

Used as an intermediate for dyes, pesticides, and rubber chemicals; [HSDB]

Comments

o-Chloroaniline is listed in a table "Examples of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) An eye irritant; Can induce methemoglobinemia; [ICSC] Negative results for skin sensitizer from guinea pig testing; [Reference #2]

Biomedical References

Methemoglobin in blood = 1.5% of hemoglobin during or end of shift

0.204 mm Hg

LC50 (rat) = 797 ppm/4h

Explanatory Notes

Flash point = 103 deg C; VP from HSDB;

Reference Link #2

MetHgb is primary toxic effect

Diseases

Occupational diseases associated with exposure to this agent:

• Methemoglobinemia, acute