3-Chloro-1-propanol

Synonyms

1-Chloro-3-hydroxypropane; 3-Chloropropanol; 3-Chlorpropan-1-ol [German]; Trimethylene chlorohydrin; 1-Propanol, 3-chloro-; 3-Chloropropanol-1; [ChemIDplus] 1-Chloro-3-propanol; 3-Chloro-1-hydroxypropane; 3-Chloropropyl alcohol; Chloro-3 propanol-1 (French DOT); [CAMEO] Chloropropanol, 3-, 1-; [NTP] UN2849

Category

Halogenated Alcohols

Description

Colorless liquid; [CAMEO]

Sources/Uses

Used to make plastics, resins, and other chemicals; [CAMEO] Used as an intermediate in organic synthesis; [NTP] "An inhibitor of triosephosphate isomerase and glyceraldehyde 3-phosphate dehydrogenase." [ChemIDplus]

Comments

Causes muscle contraction or spasticity, ulceration of the stomach, and other liver changes in oral lethal-dose studies of mice; [RTECS] May cause skin, eye, and nasal irritation; Other symptoms may include vomiting, giddiness, dizziness, incoordination, visual disturbances, and coma; May be absorbed through skin; [NTP] An irritant; Harmful by ingestion; [Alfa Aesar MSDS] See "1-Chloro-2-propanol."

Biomedical References

1.2 mm Hg

Explanatory Notes

VP from ChemIDplus;

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Solvents, acute toxic effect