Triforine

Synonyms

1,1'-Piperazine-1,4-diyldi-(N-(2,2,2-trichloroethyl)formamide); 1,4-Bis(1-formamido-2,2,2-trichloroethyl)piperazine; 1,4-Bis(2,2,2-trichloro-1-formamidoethyl)piperazine; Biformylchlorazin; CA 70203; CELA 50; CELA W 524; CME 74770; CW 524; Funginex; N,N'-(Piperazine-1,4-diylbis((trichloromethyl)methylene))diformamide; N,N'-(Piperazinediylbis(2,2,2-trichloroethylidene)) bis(formamide); N,N'-Bis(1-formamido-2,2,2-trichloroethyl)piperazine; Saprol; Triforin; W 524; Formamide, N,N'-(1,4-piperazinediylbis(2,2,2-trichloroethylidene))bis-; N,N'-(1,4-Piperazinediylbis(2,2,2-trichloroethylidene))bisformamide; Piperazine, 1,4-bis(1-formamido-2,2,2-trichloroethyl)-; N,N'-(1,4-Piperazinediyl-bis(2,2,2-trichloroethyldene))bis(formamide); N,N'-(1,4-Piperazinediylbis(2,2,2-trichloroethylidene)) bisformamide; [ChemIDplus]

Category

Fungicides

Description

White solid; [Merck Index] Colorless solid; [CAMEO] White to light brown solid; [HSDB] White solid; Formulated as emulsifiable concentrate and ready-to-use aerosol; [Reference #2]

Sources/Uses

Used as a fungicide on almonds, apples, asparagus, blueberries, cherries, hops, ornamentals, peaches, and roses; [EXTOXNET] Used as food additive, fungicide, and agricultural chemical; [Hawley] Registered in the US as fungicide for use on ornamental bushes, trees, and vines; [Reference #2]

Comments

Low acute toxicity in animals, and no cases of human poisoning reported; [EPA Pesticides] Allergic contact dermatitis reported in chrysanthemum growers; [Kanerva, p. 787; PMID 7821004] No evidence in rats of adverse effects to male or female fertility or teratogenicity; The metabolite dinitrosopiperazine is carcinogenic in mice exposed transplacentally and by lactation; [REPROTOX]

All food uses voluntarily cancelled in the US in 1996; [Reference #2]

Reference Link #1

Biomedical References

2E-07 mm Hg

LC50 (rat) > 5,120 mg/m3

Explanatory Notes

VP from HSDB;

Reference Link #2

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)