Pulegone

Synonyms

(+)-(R)-Pulegone; (+)-Pulegone; (1R)-(+)-p-Menth-4(8)-en-3-one; (R)-(+)-Pulegone; (R)-Pulegone; 1-Isopropylidene-4-methyl-2-cyclohexanone; 1-Methyl-4-isopropylidene-3-cyclohexanone; 3-Methyl-6-isopropylidenecyclohexanone; 4(8)-p-Menthen-3-one, delta-; 5-Methyl-2-(1-methylethylidene)cyclohexanone, (R)-; Pulegon; R-Pulegone; Pulegone (natural); Pulegone, d-; d-Pulegone; p-Menth-4(8)-en-3-one, (R)-(+)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (5R)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (R)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (theta)-; Pulegone; p-Menth-4(8)-en-3-one; [ChemIDplus] (5R)-5-Methyl-2-(1-methylethylidene)cyclohexanone; R-(+)-p-Menth-4(8)-en-3-one; [Merck Index]

Category

Plant Oils and Extracts

Description

Liquid with a pleasant odor between peppermint and camphor; [Merck Index] Clear light brown liquid; [Sigma-Aldrich MSDS]

Sources/Uses

A natural oil in plants of the Labiatae family; [Merck Index] Used as flavoring agent or adjuvant; [FDA] Also used in dental products, as fragrance agents, and in herbal medicines; [NTP]

Comments

All early deaths in 2-week oral studies of rats and mice at doses >300 mg/kg attributed to liver toxicity; Non-neoplastic lesions of the liver, kidney, nose, and forestomach of rats and mice observed in 2-year oral studies; Evidence for carcinogenic activity: None in male rats; some in female rats; clear evidence (liver neoplasms) in male and female mice; [NTP] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; May be harmful if swallowed or inhaled; [Sigma-Aldrich MSDS]

Biomedical References

138 mm Hg

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Other Information

No other related information on this agent was found.