Trichlorfon

Synonyms

(+-)-Trichlorfon; (2,2,2-Trichloro-1-hydroxyethyl)-phosphonic acid dimethyl; ester; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; 1-Hydroxy-2,2,2-trichloro-ethyle phosphonate de dimethyle; [French]; 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester; Aerol 1; Aerol 1 (pesticide); Agroforotox; Anthon; BAY 15922; BAY-L 1359; BAY-a 9826; Bayer 15922; Bayer L 13/59; Bayer L 1359; Bilarcil; Bovinox; Briten; Briton; Britten; Cekufon; Chlorak; Chlorfos; Chlorofos; Chloroftalm; Chlorophos; Chlorophosciclosom; Chlorophthalm; Chloroxyphos; Chlorphos; Ciclosom; Clorofos; Clorofos [Russian]; Combot; Combot equine; DEP (VAN); DEP (pesticide); DETF; Danex; Denkaphon; Depthon; Dicontal Fort; Dimethoxy-2,2,2-trichloro-1-hydroxy-ethyl phosphine oxide; Dimethoxy-2,2,2-trichloro-1-hydroxy-ethyl-phosphine oxide; Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; Dimethyl 1-hydroxy-2,2,2-trichloroethyl phosphonate; Dimethyl 2,2,2-trichloro-1-hydroxyethylphosphonate; Dimethyltrichlorohydroxyethyl phosphonate; Dimetox; Dioxaphos; Dipterex; Dipterex 50; Dipterex SL; Dipterex WP 80; Diptevur; Ditrifon; Ditriphon 50; Dylox; Dyrex; Dyvon; ENT 19,763; Equino-aid; Flibol E; Fliegenteller; Forotox; Foschlor; Foschlor 25; Foschlor R; Foschlor R-50; Foschlor R-50 (VAN); Foschlorem [Polish]; Hypodermacid; Khloroftalm; Leivasom; Loisol; Masoten; Mazoten; Methyl chlorophos; Metrifonate; Metrifonato [INN-Spanish]; Metrifonatum [INN-Latin]; Metriphonate; Metriphonatum; Neguvon; O,O Dimetil 2,2,2-trichloro 1 hidroxietil fosfonato (Portugese); O,O-Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (1-oxy-2,2,2-trichloroethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate; O,O-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosponate; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphonsaeure ester [German]; O,O-Dimethyl-(1-hydroxy-2,2,2-trichloraethyl)phosphosaeure ester; O,O-Dimethyl-(1-hydroxy-2,2,2-trichlorathyl)-phosphat [German]; O,O-Dimethyl-(2,2,2-trichloor-1-hydroxy-ethyl)-fosfonaat [Dutch]; O,O-Dimethyl-(2,2,2-trichlor-1-hydroxy-aethyl)phosphonat [German]; O,O-Dimethyl-1-hydroxy-2,2,2-trichloroethylphosphonate; O,O-Dimethyl-1-oxy-2,2,2-trichloroethyl phosphonate; O,O-Dimetil-(2,2,2-tricloro-1-idrossi-etil)-fosfonato [Italian]; OMS 800; Phoschlor; Phoschlor R50; Phosphonic acid, (1-hydroxy-2,2,2-trichloroethyl)-, dimethyl ester; Phosphonic acid, (2,2,2-trichloro-1-hydroxyethyl)-, dimethyl ester; Polfoschlor; Proxol; Ricifon; Ritsifon; Satox 20WSC; Soldep; Sotipox; Trichloorfon [Dutch]; Trichlorfon [BSI:ISO]; Trichlorfon [German]; Trichlorofon; Trichlorophon; Trichlorphon; Trichlorphon FN; Trichlorphon [ISO]; Trinex; Tugon; Tugon fly bait; Tugon stable spray; Vermicide bayer 2349; Volfartol; Votexit; WEC 50; Wotexit; [ChemIDplus] UN2783

Category

Organophosphate Insecticides

Description

White solid; [Merck Index] White solid; Formulated as soluble powder and granular products; [Reference #2]

Sources/Uses

Applied to crops, livestock, shrubs, and trees to kill cockroaches, crickets, silverfish, bedbugs, fleas, cattle grubs, flies, ticks, leafminers, and leaf-hoppers; also used to kill fish and domestic animal parasites; [EXTOXNET] Also used as therapeutic anthelmintic (schistosoma); [Merck Index] A general purpose non-agricultural systemic insecticide; Used mostly for home and golf course turf, but also used for ornamentals, food and meat processing facilities (non-food contact surfaces), and ornamental and bait fish ponds; Used in other countries as pour-on cattle treatment; [Reference #2] Used in the EU on fruit trees, vegetables, field crops, and greenhouse crops; [EFSA]

Comments

Trichlorfon is classified as "moderately toxic" with an LD50 of 450-650 mg/kg in rats. Skin sensitivity has been reported. Delayed polyneuropathy has occurred in patients who ingested large amounts. [EXTOXNET] A small number of the organophosphates (OPs) can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion and is usually nonoccupational. [Levy, p. 431] A slow release cholinesterase inhibitor; Non-enzymatically transformed into dichlorvos, the active compound; [Merck Index] A cholinesterase inhibitor that may cause nervous system effects (convulsions, respiratory failure, and death); May cause skin sensitization; Can be absorbed through skin; [ICSC] Reports of delayed neuropathy and skin sensitivity in humans; [HSDB] Produces the OP pesticide dichlorvos (DDVP) on degradation; In a study to evaluate use for treatment of Alzheimer’s disease, the LOEL (plasma and erythrocyte cholinesterase inhibition) was 5.0 mg/kg/day for a single oral dose in humans; [Reference #2] “The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline.” [TLVs and BEIs] See "Dichlorvos."

Reference Link #1

Biomedical References

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Insufficient data

0.1 mg/m3, inhalable fraction

7.8E-06 mm Hg

LC50 (rat) = 533 mg/m3

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, solid, toxic."

Reference Link #2

Yes

Predominantly motor

Not classifiable

Not Classifiable

Other Poison

Organophosphate

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Organophosphates & carbamates, acute poisoning

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)