alpha-Ketoglutaric acid
Agent Name
alpha-Ketoglutaric acid
CAS Number
328-50-7
Formula
C5-H6-O5
Major Category
Other Uses
Synonyms
2-Oxo-1,5-pentanedioic acid; 2-Oxopentanedioic acid; Alphaketoglutaric acid; Glutaric acid, alpha keto; alpha Ketoglutarate; alpha-Ketoglutaricum acidum; alpha-Oxoglutaric acid; alpha-Ketoglutarate; 2-Oxoglutaric acid; Glutaric acid, 2-oxo- (8CI); Pentanedioic acid, 2-oxo-; [ChemIDplus]
Category
Biochemical Research
Description
Solid; [Merck Index] White to off-white solid; [Acros Organics MSDS]
Sources/Uses
"Plays an important role in amino acid metabolism (transamination)"; [Merck Index] Involved in the Krebs cycle of intermediary metabolism; Has been used as a nutritional supplement; [ExPub: TERIS] Used as flavoring agent or adjuvant; [FDA]
Comments
Causes convulsions in acute intraperitoneal studies of mice; Causes other liver changes and multiple enzyme effects in 20-week intermittent oral studies of rats; [RTECS] Safe when used as a flavoring agent in food; [JECFA] An eye irritant that may cause corneal injury; [Acros Organics MSDS]
Biomedical References
Exposure Assessment
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.