Diethylene glycol monobutyl ether

Synonyms

2-(2-Butoxyethoxy)ethanol; BUCB; Butoxy diethylene glycol; Butoxydiethylene glycol; Butoxydiglycol; Butoxyethoxyethanol; Butyl Ethyl Cellosolve; Butyl carbitol; Butyl diglycol; Butyl digol; Butyl dioxitol; Diethylene glycol butyl ether; Diethylene glycol monobutyl ether; Diethylene glycol n-butyl ether; Diethylene gylcol monobutyl ether; Diglycol monobutyl ether; Dowanol DB; Ektasolve DB; Ethanol, 2,2'-oxybis-, monobutyl ether; Ethanol, 2-(2-butoxyethoxy)-; Glycol ether DB; Jeffersol DB; O-Butyl diethylene glycol; Poly-Solv DB; [ChemIDplus]

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a mild pleasant odor; [CAMEO]

Sources/Uses

Used as a solvent and diluent for polymers, resins, coatings, inks, cleaners, and metalworking fluids; [HSDB] Used as a solvent (nitrocellulose, oils, dyes, gums, soaps, and polymers) and coalescing agent in latex paints; In paints containing 1.5% w/w, painters exposed to 4-5 mg/m3; [ACGIH]

Comments

"TLV Basis" is hematologic, liver, and kidney effects; The NOAEL for rats was 250 mg/kg/day, equivalent to a worker exposed to 260 ppm; [ACGIH] In animal studies, no genotoxic or mutagenic effects and no acute adverse effects after exposure to 18 ppm; No evidence of liver, kidney, blood, or reproductive toxicity in humans; [Sullivan, p. 1204] A mild skin irritant and severe eye irritant that is absorbed through the skin; [CHS, p. 164] The toxicity of diethylene glycol ethers is lower than that of the ethylene glycol ethers. Animal studies: Can cause central nervous system depression, liver, and kidney injury; [HSDB] A skin and eye irritant; [ICSC] Rats in high-dose feeding studies for 6 weeks have decreased red blood cell counts; [CPS&Q: IUCLID Reports] "It is considered an exceptional allergen." [Kanerva, p. 1763]

Reference Link #1

Biomedical References

No

10 ppm, inhalable fraction and vapor

10 ppm, sum of the concentrations of DGBE and its acetate in air

0.02 mm Hg

Explanatory Notes

Flash point = 78 deg C; VP from HSDB;

high ambient temp required

Hemolytic anemia

Yes

Acute solvent syndrome

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Yes

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Encephalopathy, chronic solvent
• Solvents, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Metal Machining
• Painting (Solvents)
• Plastic Composites Manufacturing
• Semiconductor Manufacturing
• Silk-Screen Printing
• Textiles (Printing, Dyeing, or Finishing)