Major Category
Biological Agents
Synonyms
Croton resin; Croton tiglium L. oil; Crotonoel [German]; Oils, croton; Oleum tiglii; Olin di croton [Italian]; [ChemIDplus] Tiglium oil; [NTP]
Category
Plant Oils and Extracts
Description
Pale yellow or brownish-yellow liquid with a mild disagreeable odor; Colorless liquid with an unpleasant odor; [CAMEO] Amber viscous liquid; [NTP] Clear dark yellow liquid; [Sigma-Aldrich MSDS]
Sources/Uses
Has been used in cancer research as a co-carcinogen; Has also been used therapeutically as a counter-irritant and cathartic; [Merck Index]
Comments
A mild to severe skin irritant; Causes irritation and inflammatory effects in acute dermal studies of mice; [RTECS] "Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality." [ChemIDplus] A severe skin irritant that may cause vesiculation, necrosis, sloughing, and blisters; [CAMEO] LD50 < 50 mg/kg; A severe skin and eye irritant; [CHRIS] May cause allergic reactions on ingestion; [NTP] A mild skin irritant; [Sigma-Aldrich MSDS]
Other Information
No other related information on this agent was found.