Phenmedipham

Synonyms

3-((Methoxycarbonyl)amino)phenyl (3-methylphenyl)carbamate; 3-(Carbomethoxyamino)phenyl 3-methylcarbanilate; 3-(Methylphenyl)carbamic acid 3-((methoxycarbonyl)amino)phenyl ester; 3-Methoxycarbonyl-N-(3'-methylphenyl)-carbamat [German]; 3-Methoxycarbonylaminophenyl 3'-methylcarbanilate; 3-Methoxycarbonylaminophenyl N-3'-methylphenylcarbamate; Betanal; Carbanilic acid, m-hydroxy, methyl ester, m-methylcarbanilate (ester); EP-452; Fenmedifam; Kemifam; Methyl 3-(3-methylcarbaniloyloxy)carbanilate; Methyl 3-(m-tolylcarbamoyloxy)phenylcarbamate; Methyl N-(3-(N-(3-methylphenyl)carbamoyloxy)phenyl)carbamate; Methyl m-hydroxycarbanilate m-methylcarbanilate (ester) (8CI); Methyl m-hydroxycarbanilate, m-methylcarbanilate; Methyl-3-hydroxycarbanilate-3-methylcarbanilate; Methyl-3-m-tolycarbamoloxyphenyl carbamate; Morton EP 452; Phenmediphame [ISO-French]; S 4075; SN 4075; SN-38584; Schering 4072; Schering-38584; Spin-aid; Synbetan P; m-Hydroxycarbanilic acid methyl ester m-methylcarbanilate; Carbamic acid, (3-methylphenyl)-, 3-((methoxycarbonyl)amino)phenyl ester; [ChemIDplus]

Category

Herbicides, Other

Description

Colorless solid; [Merck Index] Colorless odorless solid; Formulated as technical solid and emulsifiable concentrate; [EPA REDs]

Sources/Uses

Used as a post-emergent herbicide; [Kanerva, p. 783] Used as a broadleaf herbicide for sugar and table beets, spinach, and Swiss chard grown for seed (over 98% used on sugar beets); [EPA REDs]

Comments

Allergic and photoallergic contact dermatitis reported in farmers; [Kanerva, p. 783] Emergency treatment: "Carbamate herbicides and fungicides"; [HSDB] The erythrocyte is the primary target of toxicity with hemolytic anemia observed in sub-chronic (rat, mouse, and dog) and chronic (rat) feeding studies; Methemoglobinemia and other hematological changes also seen in some studies; The severity of hematological effects noted in sub-chronic studies did not progress with time as evidenced in chronic studies; No developmental toxicity observed at the highest tested dose in rats (1,350 mg/kg/day) or rabbits (1,000 mg/kg/day) by gavage during gestation; [EPA REDs] May cause irritation; Toxic by skin absorption; [Aldrich MSDS]

Reference Link #1

Biomedical References

1E-11 mm Hg

Reference Link #2

Yes

MetHgb is secondary toxic effect

PACD (photoallergic contact dermatitis)

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Contact dermatitis, photoallergic

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)