Demecolcine
Agent Name
Demecolcine
Alternative Name
Colcemid
CAS Number
477-30-5
Formula
C21-H25-N-O5
Major Category
Other Uses
Synonyms
(-)-Colchamine; (-)-Demecolcine; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(alpha)heptalen-9(5H)-one; Alkaloid H 3, from colchicum antumnale; C-12669; Ciba 12669A; Colcemid; Colchamine; Colchicine, 7-deacetamido-7-(methylamino)-; Colchicine, N-deacetyl-N-methyl-; Deacetyl-N-methylcolchicine; Deacetylmethylcolchicine; Demecolcin; Demecolcina [INN-Spanish]; Demecolcinum [INN-Latin]; Desacetylmethylcolchicine; Desmecolcine; Kolchamin; Kolchicin [Czech]; Kolkamin; N-Deacetyl-N-methylcolchicine; N-Desacetyl-N-methylcolchicine; N-Desacetylmethylcolchicine; N-Methyl-N-deacetylcolchicine; N-Methyl-N-desacetylcolchicine; Omain; Omaine; Reichstein's F; Santavy's substance F; Substance F; X 153; Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; [ChemIDplus]
Category
Biochemical Research
Description
Pale yellow solid; [Merck Index] Light yellow crystalline solid; [Sigma-Aldrich MSDS]
Sources/Uses
An anti-tumor alkaloid; Used as a "cell synchronization agent, for chromosome visualization, to induce oocyte enucleation for somatic cell cloning." [Merck Index]
Comments
Causes somnolence and diarrhea in intravenous lethal-dose studies of mice; [RTECS] May cause irritation; Highly toxic by ingestion; Targets bone marrow; Teratogenic and mutagenic effects observed in laboratory studies; [Sigma-Aldrich MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
1.48E-09 mm Hg
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.