2-Ethoxyethyl acetate

Agent Name
2-Ethoxyethyl acetate
Alternative Name
EGEEA
CAS Number
111-15-9
Formula
C6-H12-O3
Major Category
Solvents
2-Ethoxyethyl acetate formula graphical representation
Synonyms
Ethylene glycol monoethyl ether acetate; 1-Acetoxy-2-ethoxyethane; 2-Aethoxy-aethylacetat [German]; 2-Ethoxy-ethylacetaat [Dutch]; 2-Ethoxyethanol acetate; 2-Ethoxyethanol, ester with acetic acid; 2-Ethoxyethyl acetate; 2-Ethoxyethylacetate; 2-Ethoxyethyle, acetate de [French]; 2-Ethoxyethylester kyseliny octove [Czech]; 2-Etossietil-acetato [Italian]; Acetate d'ethylglycol [French]; Acetate de cellosolve [French]; Acetate de l'ether monoethylique de l'ethylene-glycol; [French]; Acetato di cellosolve [Italian]; Acetic acid, 2-ethoxyethyl ester; Aethylenglykolaetheracetat [German]; Cellosolve acetate; Celosolvacetat [Czech]; EGEEA; Ektasolve EE acetate solvent; Ethanol, 2-ethoxy-, acetate; Ethoxyethyl acetate; Ethyl cellosolve acetaat [Dutch]; Ethyl cellosolve acetate; Ethylene glycol ethyl ether acetate; Ethylene glycol monoethyl ether acetylated; Ethylene glycol monoethyl ether monoacetate; Ethyleneglycol monoethyl ether acetate; Ethylglycol acetate; Ethylglykolacetat [German]; Glycol ether EE acetate; Glycol monoethyl ether acetate; Octan etoksyetylu [Polish]; Oxitol acetate; Oxytol acetate; Poly-Solv EE acetate; [ChemIDplus] UN1172
Category
Glycol Ethers (E Series)
Description
Colorless liquid with a mild odor; [NIOSH]
Sources/Uses
Used as an industrial solvent; [ACGIH]
Comments
Laboratory animals die after twelve 8-hour exposures of 450 ppm; pathological examination shows kidney damage; [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See "Glycol ethers."
Restricted
The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]
Biomedical References

Exposure Assessment

BEI
2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek;
Skin Designation (ACGIH)
Yes
TLV (ACGIH)
5 ppm
PEL (OSHA)
100 ppm
MAK
2 ppm, sum of the concentrations of CAS 110-80-5 and its acetate in air
IDLH (NIOSH)
500 ppm
Excerpts from Documentation for IDLHs
Basis for original (SCP) IDLH: Patty [1963] reported that guinea pigs survived a 1­hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2­ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm). . . . Human data: None relevant for use in determining the revised IDLH.
Vapor Pressure
2 mm Hg
Odor Threshold Low
0.06 ppm
Odor Threshold High
0.13 ppm
Lethal Concentration
LC50 (rat) = 12,100 mg/m3/8 hr
Explanatory Notes
Detection odor threshold from AIHA (mean = 0.06 ppm); Flash point = 47 deg C; VP from HSDB; See 2022 "Notice of Intended Changes" for BEI; [ACGIH TLVs and BEIs]
Half Life
"The half life for elimination was 23.6 hours." [HSDB]
Reference Link #2
NFPA
high ambient temp required

Adverse Effects

Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Reproductive Toxin
Yes

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent:

Processes