3-Methylcyclohexanone
Agent Name
3-Methylcyclohexanone
CAS Number
591-24-2
Formula
C7-H12-O
Major Category
Other Classes
Synonyms
Cyclohexanone, 3-methyl-; Methyl-3 cyclohexanone-1 [French]; [ChemIDplus] Tetrahydro-m-cresol; [JECFA] UN2297
Category
Aliphatic Ketones, Other
Description
Clear colorless to very faintly yellow liquid; [Acros Organics MSDS]
Sources/Uses
Used as flavoring agent or adjuvant; [FDA]
Comments
TLV Basis is liver effects and CNS impairment. TLV-TWA is 20 ppm for Methylcyclohexanone (mixture of the 3 isomers), CAS number 1331-22-2. Causes liver toxicity in feeding study of rats. [ACGIH] Causes changes in cardiac rate and lowered blood pressure in intravenous lethal-dose studies of dogs (LDLo = 310 mg/kg); [RTECS] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; Harmful by ingestion, inhalation, and skin absorption; [Acros Organics MSDS] See "Cyclohexanone."
Biomedical References
Exposure Assessment
TLV (ACGIH)
20 ppm
Vapor Pressure
1.5 mm Hg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Methylcyclohexanone." VP from ChemIDplus;
Adverse Effects
Neurotoxin
Acute solvent syndrome
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: