Phenylhydrazine

Synonyms

Fenilidrazina [Italian]; Fenylhydrazine [Dutch]; Hydrazine, phenyl-; Hydrazine-benzene; Hydrazinobenzene; Hydrazobenzene; Monophenylhydrazine; Phenylhydrazin [German]; Phenylhydrazine; [ChemIDplus] UN2572

Category

Hydrazines

Description

Colorless to pale-yellow liquid or solid (below 67 degrees F) with a faint, aromatic odor; [NIOSH]

Sources/Uses

Used in the synthesis of dyes and pharmaceuticals; [ACGIH]

Comments

Hemolytic anemia has been observed in workers after inhalation and dermal exposures. [ACGIH] Phenylhydrazine is a potent skin sensitizer and can cause hemolytic anemia by all routes of exposure. Toxic effects were observed in patients treated for polycythemia with doses of 0.2 G/day for 3 or 4 doses, then 0.1 G/day. Adverse effects included hemolytic anemia, liver injury, and methemoglobinemia. [HSDB] Can cause hemolytic anemia and skin sensitization; [ICSC] Causes first-degree burns on short exposure and second-degree burns on prolonged exposure; [CHRIS]

Biomedical References

Yes

0.1 ppm

5 ppm

15 ppm

Excerpts from Documentation for IDLHs

No data on acute or chronic inhalation toxicity are available on which to base the IDLH. Systemic effects described by Patty [1963] were caused by chronic exposures from oral dosing. NIOSH [1976] cited a rat oral LD50 of 188 mg/kg [Ekshtat 1965] which provides a calculated estimate of 1,300 mg/m3 (295 ppm) for the IDLH.

0.026 mm Hg

LC50 (rat) = 2,610 mg/m3

Explanatory Notes

Flash point = 88 deg C; VP from HSDB;

high ambient temp required

Hemolytic anemia

Yes

MetHgb is secondary toxic effect

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Confirmed Animal

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic
• Hemolytic anemia, acute