Fluorescein isothiocyanate

Agent Name
Fluorescein isothiocyanate
Alternative Name
FITC
CAS Number
27072-45-3
Formula
C21-H11-N-O5-S
Major Category
Dyes
Fluorescein isothiocyanate formula graphical representation
Synonyms
FITC; Fluorescein-5(or 6)-isothiocyanate; 3',6'-Dihydroxy-5(or 6)-isothiocyanatospiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one; Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 3',6'-dihydroxy-5(or 6)-isothiocyanato-; [ChemIDplus] Fluorescein 5(6)-isothiocyanate; [Sigma-Aldrich MSDS]
Category
Other Dyes
Description
Orange solid; [Merck Index] Dark yellow powder; [Sigma-Aldrich MSDS]
Sources/Uses
Used as a fluorescent indicator to probe biological systems and monitor sewage; [Merck Index]
Comments
A mixture of the 5- and 6-isothiocyante isomers; [Merck Index] A skin sensitizer in animal experiments; [Reference #1] May cause irritation, respiratory sensitization, and lung injury; [Sigma-Aldrich MSDS] See "Fluorescein-5-isothiocyanate." See "Fluorescein."
Reference Link #1
Transient receptor potential ankyrin 1 activation enhances hapten sensitization in a T-helper type 2-driven fluorescein isothiocyanate-induced contact hypersensitivity mouse model.
Biomedical References
Search PubMed

Adverse Effects

Skin Sensitizer
Yes

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: