Ethionine
Agent Name
Ethionine
CAS Number
13073-35-3
Formula
C6-H13-N-O2-S
Major Category
Other Uses
Synonyms
(L)-Ethionine; Butanoic acid, 2-amino-4-(ethylthio)-, (S)-; ETH; Homocysteine, S-ethyl-; L-2-Amino-4-(ethylthio)butyric acid; L-Ethionine; L-Homocysteine, S-ethyl-; L-S-Ethylhomocysteine; Butyric acid, 2-amino-4-(ethylthio)-, L-; S-Ethyl-L-homocysteine; [ChemIDplus] Homocysteine S-ethyl ether; [Merck Index]
Category
Biochemical Research
Description
Solid; [Merck Index]
Sources/Uses
"An antimetabolite and methionine antagonist that interferes with amino acid incorporation into proteins and with cellular ATP utilization. It also produces liver neoplasms." [ChemIDplus] Toxic analogue of the essential amino acid methionine; Produced by various microorganisms such as E. coli; Used as an experimental carcinogen and in biological research; Not commercially produced in the US; [HSDB]
Comments
Causes diffuse hepatitis and acute renal failure in acute oral studies of rats; Causes hepatitis in 35-day constant oral studies of rats; [RTECS] A hepatotoxin; [HSDB] A skin and strong eye irritant; Targets the liver; [Sigma-Aldrich MSDS]
Biomedical References
Adverse Effects
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.