Pyrrolidine
Agent Name
Pyrrolidine
Alternative Name
Tetramethyleneimine
CAS Number
123-75-1
Formula
C4-H9-N
Major Category
Nitrogen Compounds
Synonyms
1-Azacyclopentane; Azacyclopentane; Azolidine; Butylenimine; Perhydropyrrole; Prolamine; Pyrrole, tetrahydro-; Pyrrolidine ring; Tetrahydropyrrole; Tetramethyleneimine; [ChemIDplus] UN1922
Category
Amines, Cyclic
Description
Colorless to yellow liquid with ammonia-like odor; [HSDB]
Sources/Uses
Used as an intermediate in chemical production and as a curing agent in epoxy resin systems; [HSDB]
Comments
Corrosive to skin; [Quick CPC] In high-dose animal studies, causes damage to the liver, kidneys, and CNS (seizures); In 6-hour inhalation studies with concentrations of 2600 ppm, no rats died. [HSDB] Corrosive to skin and eyes; A respiratory tract irritant; May have effects on the nervous system; [ICSC] Safe when used as a flavoring agent in food; [JECFA] Causes convulsions in inhalation lethal-concentration studies of mice and oral lethal-dose studies of rats; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion and inhalation; [Alfa Aesar MSDS]
Biomedical References
Exposure Assessment
Vapor Pressure
62.7 mm Hg
Lethal Concentration
LC50 (mouse) = 1,300 mg/m3/2hr
Explanatory Notes
Flash point = 37 deg F; [CAMEO] VP from HSDB;
NFPA
may ignite at ambient temp
Adverse Effects
Toxic Pneumonitis
Yes
Neurotoxin
Other CNS neurotoxin
Hepatotoxin
Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Processes
Industrial Processes with risk of exposure: