Guanidine thiocyanate
Agent Name
Guanidine thiocyanate
CAS Number
593-84-0
Formula
C-H5-N3.C-H-N-S
Major Category
Other Uses
Synonyms
Guanidine, monothiocyanate; Guanidinium thiocyanate; Thiocyanic acid, compd. with guanidine (1:1); [ChemIDplus] UN1759
Category
Biochemical Research
Description
White crystalline solid; Hygroscopic; [Sigma-Aldrich MSDS]
Sources/Uses
"A powerful chaotropic agent." [ChemIDplus] "A chaotropic agent is a substance which disrupts the structure of, and denatures, macromolecules such as proteins and nucleic acids (e.g. DNA and RNA)." [Wikipedia] Used for RNA isolation and can solubilize proteins; [Santa Cruz Biotechnology]
Comments
Intraperitoneal LD50 (mouse) = 300 mg/kg; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See "Guanidine." See "Sodium thiocyanate."
Biomedical References
Exposure Assessment
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Corrosive solid, n.o.s."
Adverse Effects
Toxic Pneumonitis
Yes
Dermatotoxin
Skin burns
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.