Phenyl isocyanate

Synonyms

Benzene, isocyanato-; Carbanil; Fenylisokyanat [Czech]; Isocyanatobenzene; Isocyanic acid, phenyl ester; Karbanil [Czech]; Mondur P; Phenyl carbonimide; Phenylcarbimide; UN2487; [ChemIDplus]

Category

Monoisocyanates

Description

Liquid with an acrid odor; [Merck Index]

Sources/Uses

Used as a chemical intermediate and analytical reagent; [Hawley]

Comments

A lachrymator and strong irritant of the eyes and respiratory tract; [HSDB] No quantitative data from human studies; The lung appears to be the target organ in lethal concentration studies of experimental animals. "The 1-hour LC50 was 12.6 ppm with most deaths recorded 8 to 12 days post-exposure." TLV Basis is upper respiratory tract irritation; Appears to have sensitization potential (skin and respiratory); [ACGIH] Danger of skin and airway sensitization; [MAK] See "Methyl isocyanate" and "Monoisocyanates."

Biomedical References

Yes

Yes

0.005 ppm

0.015 ppm

2.57 mm Hg

LC50 (rat) = 4.6 ppm/4H

Explanatory Notes

VP from HSDB;

Yes

Yes

Yes

Yes

Diseases

Occupational diseases associated with exposure to this agent:

• Asthma, occupational
• Contact dermatitis, allergic
• Pneumonitis, toxic