Propargyl bromide

Synonyms

1-Brom-2-propin [Czech]; 1-Bromo-2-propyne; 1-Propyne, 3-bromo-; 2-Propynyl bromide; 3-Bromo-1-propyne; 3-Bromopropyne; Gamma-bromoallylene; Propyne, 3-bromo-; Propynyl bromide; gamma-Bromoallylene; UN2345; [ChemIDplus]

Category

Fumigants

Description

Colorless liquid with a pungent odor; [NJ-HSFS]

Sources/Uses

Used as a fumigant, an alkylating agent, and a chemical intermediate; [HSDB]

Comments

In inhalation studies, all rats die when exposed to 1000 ppm for 1 hour or 120 ppm for 7 hours. Minor liver and kidney damage occurs at lethal doses. [HSDB] Can burn the skin; A strong lacrimating agent; Inhalation of high concentrations can cause acute pneumonitis; [CAMEO] Undiluted liquid can produce irreversible corneal damage; At concentrations >1500 ppm, can cause coughing, extreme respiratory distress, and delayed pulmonary edema; [AIHA]

Biomedical References

108 mm Hg

Explanatory Notes

Flash point = 50 deg F; Sensitive to shock; Can form explosive metal acetylides after contact with copper, mercury, and silver; [CAMEO] Odor threshold <2 ppm by volume; [AIHA] VP from HSDB;

may ignite at ambient temp

0.1 ppm

Yes

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Skin burns

Diseases

Occupational diseases associated with exposure to this agent:

• Fumigants, acute toxic effect

Processes

Industrial Processes with risk of exposure:

• Farming (Pesticides)