Major Category
Other Uses
Synonyms
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; Aerrane; Aerrane (Veterinary); Compound 469; Forane; Forene; IsoFlo; Isoflurano [INN-Spanish]; Isofluranum [INN-Latin]; R-E 235dal; Terrell; Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; Isoflurane [Anaesthetics, volatile]; [ChemIDplus] ISF; Pentafluoran; [RTECS] Isoflurane liquid; Isoflurane USP; [Abbott Laboratories MSDS]
Category
Waste Anesthetic Gases
Description
Clear colorless liquid with a mild odor; [Merck Index] Musty ethereal odor; [Abbott Laboratories MSDS]
Sources/Uses
Used as a special solvent and as an inhalation anesthetic; [Merck Index] "A stable, non-explosive inhalation anesthetic, relatively free from significant side effects." [ChemIDplus]
Comments
A skin, eye, and respiratory tract irritant; May cause CNS and cardiovascular system effects; [ICSC] Occupational asthma confirmed three workers exposed to Sevoflurane and Isoflurane; [Malo] 2021 TLV Basis: embryo damage, maternal body weight effects, CNS impairment; [ACGIH] Mice exposed to concentrations of 0.6% for 4hr/day during gestation produced smaller litters, delayed ossification, and increased frequency of cleft palate (maternal toxicity shown by weight reduction); Chronic exposure of mice to low anesthetic or sub-anesthetic doses demonstrated no evidence of effects male or female fertility, reproductive loss, or early postnatal fetal wastage; A more recent study associated chronic exposure with fetal growth retardation; Chronic exposure in rabbits produced significantly reduced sperm concentrations and motility; [REPROTOX] May cause drowsiness or dizziness; [Abbott Laboratories MSDS]
Skin Designation (ACGIH)
No
Lethal Concentration
LC50 (rat) = 15,300 ppm/3hr
Neurotoxin
Acute solvent syndrome
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Not Classifiable
Diseases
Occupational diseases associated with exposure to this agent: