Isoflurane
Agent Name
Isoflurane
CAS Number
26675-46-7
Formula
C3-H2-Cl-F5-O
Major Category
Other Uses
Synonyms
1-Chloro-2,2,2-trifluoroethyl difluoromethyl ether; 2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; Aerrane; Aerrane (Veterinary); Compound 469; Forane; Forene; IsoFlo; Isoflurano [INN-Spanish]; Isofluranum [INN-Latin]; R-E 235dal; Terrell; Ethane, 2-chloro-2-(difluoromethoxy)-1,1,1-trifluoro-; Ether, 1-chloro-2,2,2-trifluoroethyl difluoromethyl; Isoflurane [Anaesthetics, volatile]; [ChemIDplus] ISF; Pentafluoran; [RTECS] Isoflurane liquid; Isoflurane USP; [Abbott Laboratories MSDS]
Category
Waste Anesthetic Gases
Description
Clear colorless liquid with a mild odor; [Merck Index] Musty ethereal odor; [Abbott Laboratories MSDS]
Sources/Uses
Used as a special solvent and as an inhalation anesthetic; [Merck Index] "A stable, non-explosive inhalation anesthetic, relatively free from significant side effects." [ChemIDplus]
Comments
A skin, eye, and respiratory tract irritant; May cause CNS and cardiovascular system effects; [ICSC] Occupational asthma confirmed three workers exposed to Sevoflurane and Isoflurane; [Malo] 2021 TLV Basis: embryo damage, maternal body weight effects, CNS impairment; [ACGIH] Mice exposed to concentrations of 0.6% for 4hr/day during gestation produced smaller litters, delayed ossification, and increased frequency of cleft palate (maternal toxicity shown by weight reduction); Chronic exposure of mice to low anesthetic or sub-anesthetic doses demonstrated no evidence of effects male or female fertility, reproductive loss, or early postnatal fetal wastage; A more recent study associated chronic exposure with fetal growth retardation; Chronic exposure in rabbits produced significantly reduced sperm concentrations and motility; [REPROTOX] May cause drowsiness or dizziness; [Abbott Laboratories MSDS]
Reference Link #1
Biomedical References
Exposure Assessment
Skin Designation (ACGIH)
No
TLV (ACGIH)
50 ppm
MAK
2 ppm
Vapor Pressure
330 mm Hg
Lethal Concentration
LC50 (rat) = 15,300 ppm/3hr
Adverse Effects
Asthma
Yes
Neurotoxin
Acute solvent syndrome
Reproductive Toxin
Yes
IARC Carcinogen
Not classifiable
ACGIH Carcinogen
Not Classifiable
Diseases, Processes, and Activities Linked to This Agent
Diseases
Occupational diseases associated with exposure to this agent: