Musk ambrette

Agent Name
Musk ambrette
CAS Number
83-66-9
Formula
C12-H16-N2-O5
Major Category
Nitrogen Compounds
Musk ambrette formula graphical representation
Synonyms
1-(1,1-Dimethylethyl)-2-methoxy-4-methyl-3,5-dinitrobenzene; 2,4-Dinitro-3-methyl-6-tert-butylanisole; 2,6-Dinitro-3-methoxy-1-methyl-4-tert-butylbenzene; 2,6-Dinitro-3-methoxy-4-tert-butyltoluene; 4-Methoxy-1,3-dinitro-2-methyl-5-tert-butylbenzene; 4-tert-Butyl-3-methoxy-1-methyl-2,6-dinitrobenzene; 4-tert-Butyl-3-methoxy-2,6-dinitrotoluene; 6-tert-Butyl-3-methyl-2,4-dinitroanisole; Amber musk; Ambrette musk; Artificial musk ambrette; Musk ambrette (artificial); Synthetic musk ambrette; Anisole, 6-t-butyl-3-methyl-2,4-dinitro-; Anisole, 6-tert-butyl-3-methyl-2,4-dinitro- (8CI); Benzene, 1-(1,1-dimethylethyl)-2-methoxy-4-methyl-3,5-; dinitro-; [ChemIDplus]
Category
Other Aromatics (Nitrogen)
Description
Pale yellow solid with a heavy floral-musky odor; [HSDB] Yellow solid; [Alfa Aesar MSDS]
Sources/Uses
Used as a perfume fixative; [HSDB] Used as a flavoring agent; [FDA] Used in organic synthesis; [NTP] Permitted for use as an inert ingredient in non-food pesticide products; [EPA] "Musk is a class of aromatic substances commonly used as base notes in perfumery." [Wikipedia]
Comments
A moderate skin irritant; Causes spinal cord demyelination and changes in testicular weight in 90-day dermal studies of rats; Causes muscle weakness, weight loss, brain and spinal cord demyelination in repeated-dose oral studies of rats; [RTECS] "Widely used fragrance implicated in contact photosensitivity." [ChemIDplus] Positive photopatch test results and photoallergic contact dermatitis have been reported; [HSDB] Evidence of photosensitivity, neurotoxicity, and penetration through human skin with slow excretion; No skin sensitization observed in maximization study of 25 volunteers; [EC: SCCNFP] A skin and moderate eye irritant; Toxic by ingestion; [Alfa Aesar MSDS]
Restricted
Prohibited for use as a fragrance ingredient in the EU; [EC: SCCNFP]
Biomedical References

Exposure Assessment

Vapor Pressure
1.31E-05 mm Hg

Adverse Effects

Neurotoxin
Other CNS neurotoxin
Dermatotoxin
PACD (photoallergic contact dermatitis)
IARC Carcinogen
Not classifiable

Diseases, Processes, and Activities Linked to This Agent

Diseases

Occupational diseases associated with exposure to this agent: