N-Methyl-N-(trimethylsilyl)trifluoroacetamide
Agent Name
N-Methyl-N-(trimethylsilyl)trifluoroacetamide
CAS Number
24589-78-4
Formula
C6-H12-F3-N-O-Si
Major Category
Metals
Synonyms
MSTFA; N-Methyl-N-trimethylsilyltrifluoroacetamide; Acetamide, 2,2,2-trifluoro-N-methyl-N-(trimethylsilyl)-; [ChemIDplus] UN1993
Category
Metalloid Compounds (Silicon)
Description
Colorless liquid; [Sigma-Aldrich MSDS]
Sources/Uses
"Derivatization, especially silylation, is commonly used to identify and quantify both known and unknown compounds using GC-MS. It is not limited to small molecules. Even peptides can be silylated, especially when the introduction of deuterium is desired. N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a very versatile reagent because it can be used to derivatize many of the functional groups commonly found in organic compounds. It operates by attachment of a nonpolar trimethylsilyl (TMS) group." [Sigma-Aldrich]
Comments
Causes decreased immune response in intraperitoneal lethal-dose studies of mice (LDLo = 1,000 mg/kg); [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See "N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide." See "N-Methyl-bis(trifluoroacetamide)."
Biomedical References
Exposure Assessment
Explanatory Notes
Vapor pressure = 8.8 mm Hg at 27 deg C; [Sigma-Aldrich MSDS] The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s."
Diseases, Processes, and Activities Linked to This Agent
Other Information
No other related information on this agent was found.