p-Bromofluorobenzene

Synonyms

1-Bromo-4-fluorobenzene; 1-Fluoro-4-bromobenzene; 4-Bromofluorobenzene; 4-Fluoro-1-bromobenzene; 4-Fluorobromobenzene; 4-Fluorophenyl bromide; p-Fluorobromobenzene; p-Fluorophenyl bromide; Benzene, 1-bromo-4-fluoro-; [ChemIDplus] 4-Bromo-1-fluorobenzene; 4-Fluorobenzene bromide; [CAMEO] 4-BFB; [NTP] UN1993

Category

Halogenated Monoaromatics

Description

Colorless to slightly yellow liquid; [NTP] Colorless liquid with an aromatic odor; [Alfa Aesar MSDS]

Sources/Uses

Used as an intermediate for agrochemicals, in organic syntheses, and as a tuning, internal, or surrogate standard for gas chromatography/mass spectrometry in the determination of volatile organic compounds; [NTP]

Comments

A skin and eye irritant in rabbits; A mild skin sensitizer in guinea pigs (20% sensitization rate in the Magnusson and Kligman test); Acute oral and inhalation studies of rats produced tremor, changes in motor activity, ataxia, and/or dyspnea; Structurally similar compounds are hepatotoxins and animal carcinogens; [NTP] A mild skin and strong eye irritant; Harmful by inhalation; [Alfa Aesar MSDS] See "p-Dichlorobenzene."

Biomedical References

2.84 mm Hg

LC50 (rat) = 18,000 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Flammable liquid, n.o.s." VP from ChemIDplus;

Yes

Hepatoxic (a) from occupational exposure (secondary effect) or (b) in animal studies or in humans after ingestion

Diseases

Occupational diseases associated with exposure to this agent:

• Contact dermatitis, allergic