Agent Name
Pertussis toxins
Major Category
Biological Agents
Synonyms
Bordetella pertussis; Bordetella pertussis toxin; Histamine-sensitizing factor; IAP; Islet activating protein; Leukocytosis-promoting factor; Lymphocytosis-promoting factor; Pancreatic islet-activating proteins; Pertussigen; Pertussigen (Bordetella pertussis); Proteins, pancreatic islet-activating; Proteins, specific or class, pancreatic islet-activating; Toxins, exo-, pertussis; Toxins, pertussis; [ChemIDplus] Pertussis toxin, from Bordetella pertussis; [Sigma-Aldrich MSDS] UN3462
Category
Bacterial Toxins
Sources/Uses
"Any of various biologically active proteins or toxins elaborated by Bordetella pertussis that cause the symptoms of whooping cough. Some activate pancreatic islets, others inhibit the adenylate cyclase cascade and some cause lymphocytosis." [ChemIDplus] "B. pertussis, the causative agent of whooping cough, produces several toxins that have striking effects in experimental systems and are hypothesized to be major contributors to the pathogenesis of the clinical illness." [PPID, p. 30]
Comments
Causes lachrymation, changes in motor activity, and weight loss in intravenous lethal-dose studies of rats and mice; [RTECS] May cause irritation; Highly toxic by inhalation; Toxic by ingestion and skin absorption; Potential neurotoxin; [Sigma-Aldrich MSDS] See "Pertussis" at https://iddx.com/.
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."
Other Information
No other related information on this agent was found.